Project description:Abstract. The adhesion of bacteria to medical implants and formation of biofilms is a growing healthcare problem that accounts for a significant proportion of hospital-acquired infections globally. Insects, including cicada and dragonfly, have evolved nanoprotrusions-protruding arrays on their wings that rupture bacteria on contact. This has inspired the design of antibacterial implant surfaces with insect wing mimetic nanopillarsarrays . Here we characterise the physiological and morphological responses of bacteria to dragonfly wing mimetic nanowirenanopillars arrays, with the aim of determining the mechanistic basis for antibacterial activity. Dragonfly wing mimetic nanowirenanopillars arrays induce deformation and penetration of Gram-positive and Gram-negative bacterial envelopes, but do not rupture or lyse bacteria. NanowireNanopillars also have capacity to impede bacterial division and trigger reactive oxygen species production oxidative stress responses, leading to the increased abundance of oxidative stress proteins. NanowireNanopillar-induced oxidative stress represents a novel antibacterial mechanism of biomimetic nanotopographies .arrays Better understanding of this could prove invaluable for enhancing the bactericidal performance of nanotextured materials for next generation antibacterial medical implants

2020-05-27 | PXD017078 | Pride

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