Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

GK and Wistar rats

ABSTRACT: Whole genome sequencing of GK and Wistar rats.

PROVIDER: PRJEB6678 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR557524_1.fastq.gz	Fastqsanger.gz
	ERR557524_2.fastq.gz	Fastqsanger.gz
	ERR557525_1.fastq.gz	Fastqsanger.gz
	ERR557525_2.fastq.gz	Fastqsanger.gz
	ERR557526_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 86

Similar Datasets

Array CGH between GK and Wistar Rats for Detecting Copy Number Variations

Project description:The Goto-Kakizak (GK) rat, a nonobese animal model of Type 2 diabetes (T2D), were developed by repeated inbreeding of glucose-intolerent individuals selected from Wistar rats. During their development, GK rats suffer from reduced beta-cell mass and insulin resistance spontaneously (T2D phenotype), which are supposed to be caused by loci holding different genotypes between GK and Wistar rats. This array CGH experiment can detect loci which show different copy numbers (genotype) between GK and Wistar rats. These loci serve as a valuable repository for mining candidates contributing to the pathogenesis of T2D.

2010-12-31 | GSE21387 | GEO

Array CGH between GK and Wistar Rats for Detecting Copy Number Variations

2010-12-31 | E-GEOD-21387 | biostudies-arrayexpress

MicroRNA expression profiling in diabetic GK rat model

Project description:MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function with type 2 diabetes, we have used an oligonucleotide microarray to monitor miRNA expression profiles of GK and Wistar rats’ muscle. We found 7 miRNAs were down-expressed and 2 were over-expressed in the muscle of GK rats. Among them, miR-24 showed the most prominent change. P38 MAPK, which is a direct target of miR-24 also showed expression difference. All the data give a clue that miR-24 might be associated with diabetes through down regulation of p38 MAPK.

2008-12-31 | GSE13920 | GEO

Expression data from Chronic Unpredict Mild Stress-induced depression in GK rats‘ liver

Project description:To explored the mechanism of pharmacokinetic perturbation in chronic unpredicted mild stress (CUMS) resulting depression, CUMS-induced depression animal model with spontaneous diabetic GK rats were established. The expression profile in GK rats' livers were screened using Affymetrix Rat 230 2.0 Array.

2017-09-25 | GSE94988 | GEO

SAGE profile of rat hippocampus mRNA from Wistar rats

Project description:SAGE profile of rat hippocampus mRNA from Wistar rats

2010-12-01 | GSE25750 | GEO

Spinal microRNA expression signature in male wistar rats exposed to repeated psychological stress

Project description:To test the effect of chronic water avoidance stress on spinal microRNA expression profile in male wistar rats.

2015-07-01 | GSE67831 | GEO

Wistar rats with iron deficiency and repletion and Belgrade rats normally fed or fed iron in drinking water: villus

Project description:Gene expression along the crypt-villus (C-V) axis was analyzed using cryostat sectioning to isolate fractions representing the crypts (bottom) and villus tops (top). These fractions were used for analyzing gene expression in iron replete Wistar rats (++), iron deficient Wistar rats (low iron), and in iron deficient Wistar rats fed iron for 3 and 6 days (iron-fed). Differences were observed between the crypts and villus tops in the expression of genes associated with Wnt and BNP signaling, cell proliferation and apoptosis, lipid and iron transport and metabolism. Gene expression in villus crypts and tops was also compared between Wistar and Belgrade rats (bb) and Belgrade rats fed iron (iron-fed) particularly as related to iron absorption and metabolism to define the affects of the mutation in DMT1 in the Belgrade rat on the expression of genes related to iron absorption and metabolism and the response to iron feeding. Keywords: iron stress response

2010-05-01 | GSE7970 | GEO

Spinal gene expression signature in male wistar rats exposed to repeated psychological stress

Project description:To test the effect of chronic water avoidance stress on spinal gene expression profile in male wistar rats.

2015-07-01 | GSE67830 | GEO