Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Whole transcriptome profiling of the MPTP neurotoxic mice model

ABSTRACT: Whole transcriptome profiling of the MPTP neurotoxic mice model reveals potential targets to modulate gene expression

PROVIDER: PRJEB6957 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR577507.fastq.gz	Fastqsanger.gz
	ERR577508.fastq.gz	Fastqsanger.gz
	ERR577509.fastq.gz	Fastqsanger.gz
	ERR577510.fastq.gz	Fastqsanger.gz
	ERR577511.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 11

Similar Datasets

Gene expression changes in multiple brain regions of a mouse MPTP model of Parkinson's disease

Project description:In Parkinson’s disease (PD), the progressive loss of substantia nigra dopamine cells has been associated with their vulnerability to oxidative stress, inflammation, and mitochondrial dysfunction. To identify multiple gene transcription alterations that may potentially underlie early stages of related degenerative processes in brain, we used the subcrhonic MPTP mouse model of PD and microarray analysis at 4 days post-MPTP when neurotoxic activity is maximal. Since PD results in gene changes throughout the brain, we assessed MPTP's effects in multiple regions: frontal cortex, striatum and midbrain. Keywords: neurotoxic response

2008-10-21 | GSE7707 | GEO

Transcription profiling of mouse multiple brain regions for a MPTP model of Parkinsons disease

Project description:In Parkinsonâ??s disease (PD), the progressive loss of substantia nigra dopamine cells has been associated with their vulnerability to oxidative stress, inflammation, and mitochondrial dysfunction. To identify multiple gene transcription alterations that may potentially underlie early stages of related degenerative processes in brain, we used the subcrhonic MPTP mouse model of PD and microarray analysis at 4 days post-MPTP when neurotoxic activity is maximal. Since PD results in gene changes throughout the brain, we assessed MPTP's effects in multiple regions: frontal cortex, striatum and midbrain. Experiment Overall Design: Mus musculus adults were randomly assigned to either MPTP or saline treatment groups. Brain regions of interest (frontal cortex, striatum and midbrain) were dissected from both groups for RNA extraction and hybridization on Affymetrix microarrays.

2008-10-26 | E-GEOD-7707 | biostudies-arrayexpress

Genes regulated in MPTP-treated macaques

Project description:MPTP treated Macaca fascicularis prefrontal cortices compared to saline treated and untreated controls Keywords: Disease model

2007-02-13 | GSE4550 | GEO

Expression data from naM-CM-/ve and MPTP-exposed cholinergic transgenic mice

Project description:PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology. The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the first drugs used for symptomatic treatment of PD. Of note, MPTP intoxication is a model of choice for symptomatic neuroprotective therapies since it have been quite predictive. Mice were exposed to the dopaminergic neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), with or without the protective acetylcholinesterase (AChE-R) variant. Transgenic AChE-S (the synaptic variant), AChE-R (the shorter, protective variant) and FVB/N control mice were included in this study. Two brain regions were examined: the pre-frontal cortex (PFC) and the striatal caudate-putamen (CPu). Each condition (i.e brain region and transgenic variant) was examined on both naive and MPTP-exposed mice. 29 microarrays including hybridizations of control FVB/N PFC, control FVB/N CPu,control S transgenics PFC, control S transgenics CPu, control R transgenics PFC, control R transgenice CPu, MPTP FVB/N PFC, MPTP FVB/N CPu, MPTP S transgenics PFC, MPTP S transgenics CPu, MPTP R transgenics PFC and MPTP R transgenice CPu mRNA.

2012-01-09 | E-GEOD-31458 | biostudies-arrayexpress

Whole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity

Project description:We characterized the transcriptomic profiles of cells from the substantia nigra (SN) of mice with co-injection with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and selective inhibitor of GCase activity (conduritol-β-epoxide, (CBE)) to mimic PD bearing GCase dysfunction (MPTP+CBE), mice treated with MPTP, mice treated with CBE and control mice treated with injec-tion of sodium chloride (NaCl) (vehicle).

2023-08-31 | E-MTAB-13244 | biostudies-arrayexpress

Cell type- and region-specific transcriptome of an MPTP-induced mouse model of Parkinson’s disease

Project description:Aiming to gain brain region- and cell type-specific resolution in gene expression profiling during PD pathogenesis, we applied the translating ribosome affinity purification (TRAP) technique to enrich the ribosome-bound mRNA of DaNs, microglia and astrocyte, for RNA-Seq and analysis in a mouse MPTP model of PD.

2022-10-15 | GSE213100 | GEO

Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture

Project description:It has been shown that acupuncture at acupoints GB34 and LR3 inhibits the degeneration of nigrostriatal neurons in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinsonâ??s disease. This preventative effect of peripheral acupuncture stimulation is hypothesized to be transmitted through the spinal cord to the nigrostriatal neurons. The gene expression profile changes following acupuncture at the acupoints were investigated in the cervical spinal cord of an MPTP-induced parkinsonism model using an Affymetrix genechip mouse gene 1.0 ST array. C57BL/6 mice were divided into four experimental groups; â? C: Control, â?¡ M: MPTP-treatment only, â?¢ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, â?£ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from the cervical spinal cord regions of each experimental group (4 experimental group Ã? 2 samples of each experimental group = total 8 samples).

2010-10-23 | E-GEOD-24830 | biostudies-arrayexpress

gene expression in low and high mPTP opening cells

Project description:We found high mPTP opening cells were more effcient to reprogramming compare to the low mPTP opening cells

2020-06-16 | GSE100103 | GEO

Expression data from naïve and MPTP-exposed cholinergic transgenic mice

2012-01-09 | GSE31458 | GEO

Gene expression data from cervical spinal cord regions of MPTP-intoxicated mouse by acupuncture

2010-10-23 | GSE24830 | GEO