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Genetic Diversity and Serotyping of Streptococcus agalactiae Clinical Isolates from Saudi Arabia

ABSTRACT: Genomic insights into the diversity, virulence, and resistance of Group B Streptococcus Clinical isolates from Saudi Arabia

PROVIDER: PRJEB70279 | ENA |

REPOSITORIES: ENA

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Genetic Diversity and Serotyping of Streptococcus agalactiae Clinical isolates from Saudi Arabia

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whole genome sequencing of Staphylococcus aureus from Saudi Arabia

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Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia

Project description:Whole transcript expression was profiled using the Affymetrix 1.0 array in human bronchial epithelial cells exposed to PM collected from Saudi Arabia for 1 or 4 days. The differentially expressed genes were identified and analyzed for enriched networks and pathways using Ingenuity Pathway Analysis (IPA). We have identified 140 and 230 genes that significantly changed more than 1.5 fold after PM exposure for 1 or 4 days, respectively. IPA analysis revealed that different exposure durations triggered distinct pathways. Genes involved in NRF2-mediated response to oxidative stress were up-regulated after 1 day exposure. In contrast, cells exposed for 4 days exhibited significantly changes in genes related to cholesterol and lipid synthesis pathways.

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Characterization of MRSA isolates from a hospital in Saudi Arabia

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Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia

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MDR UPEC in Saudi Arabia

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Application of Array CGH technique for the clinical diagnosis of developmental delay and congenital malformations in Saudi Arabia [400k]

Project description:Chromosomal imbalances are implicated in the etiology of developmental delay (DD) and congenital malformation (CM). We therefore conducted high resolution array comparative genomic hybridization (array CGH) of sixty three Saudi patients [11 by Agilent-001850/CGH1x244A and 52 by Agilent-014693/CGH2x400k] for investigating and understanding the genetic heterogeneity underlying DD/CM. A total of 76 disease associated copy number variants (CNVs) were detected in twenty four patients including 1p36, 1q21, 3p23, 6p24, 7q11, 8q24, 9q33, 10p14, 11p15, 11q12, 11q24, 13q21, 15q13, 16p13, 18q23, trisomy 18, 20q11, 21q22, 22q11.21, 47,XXY and 45,X0. The diagnosis rate of array CGH was 2.6 times higher than karyotyping.

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Application of Array CGH technique for the clinical diagnosis of developmental delay and congenital malformations in Saudi Arabia [244k]

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Identification of a transcriptomic signature of X chromosome overdosage in Saudi Klinefelter syndrome iPSCs.

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