Project description:Biofilm formation by the environmental and clinical contaminant Mycobacterium fortuitum causes economic losses and serious threat to human health, as a consequence of its increasing contribution to nosocomial infections. There are no reports that elucidate physiological adaptations taking place during its planktonic to biofilm transition. The present study was hence carried out considering the global proteome of the mycobacterium. This is the first description of a global proteomic investigation into M. fortuitum biofilm. Scrutiny of biological functions in the two states provided insights into the phenotypic switch, and fundamental pathways associated with M. fortuitum pathobiology.
Project description:aCGH data was used in Paradigm analysis for exploration of networks affected by copy number and gene expression changes based on mutation spectra of recurrently mutated genes in breast cancer.
2012-06-21 | GSE35189 | GEO
Project description:Air Microbial Sequencing in Fermentation Workshop of Dark Tea
Project description:<p>The Metabolomics workshop on experimental and data analysis training for untargeted metabolomics was hosted by the Proteomics Society of India in December 2019. The Workshop included six tutorial lectures and hands-on data analysis training sessions presented by seven speakers. The tutorials and hands-on data analysis sessions focused on workflows for liquid chromatography-mass spectrometry (LC-MS) based on untargeted metabolomics. We review here three main topics from the workshop which were uniquely identified as bottlenecks for new researchers: a) experimental design, b) quality controls during sample preparation and instrumental analysis and c) data quality evaluation. Our objective here is to present common challenges faced by novice researchers and present possible guidelines and resources to address them. We provide resources and good practices for researchers who are at the initial stage of setting up metabolomics workflows in their labs.</p><p><br></p><p>Complete detailed metabolomics/lipidomics protocols are available online at <a href='https://www.embl.de/mcf/metabolomics-core-facility/protocols/index.html' rel='noopener noreferrer' target='_blank'>EMBL-MCF protocol</a> including <a href='https://www.embl.de/mcf/metabolomics-core-facility/video-tutorials/index.html' rel='noopener noreferrer' target='_blank'>video tutorials</a>.</p>
Project description:Cancer: Surviving and Thriving is a 6-week workshop for cancer survivors. The overall goal of the study is to determine whether an online cancer survivor education and support workshop can have lasting beneficial effects in helping survivors improve their self-management of health skills and quality of life.