Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of BRAF-wildtype and BRAF-V600E_knock-in healthy colon organoids

ABSTRACT: RNA-seq of BRAF-wildtype and BRAF-V600E_knock-in healthy colon organoids

PROVIDER: PRJEB72885 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR12687448_1.fastq.gz	Fastqsanger.gz
	ERR12687448_2.fastq.gz	Fastqsanger.gz
	ERR12687449_1.fastq.gz	Fastqsanger.gz
	ERR12687449_2.fastq.gz	Fastqsanger.gz
	ERR12687450_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

RNA-seq of BRAF-wildtype and BRAF-V600E_knock-in healthy colon organoids

Project description:We aimed to investigate transcriptional changes in human healthy colon organoids where the BRAF-V600E mutation was knocked-in by means of CRISPR genome editing. RNAseq was performed at USEQ at the UMC Utrecht (The Netherlands).

2024-03-08 | E-MTAB-13842 | biostudies-arrayexpress

Illumina Infinium HumanMethylation EPIC beadchip profiling of BRAF-V600E_knock-in and BRAF-wildtype human colon organoids

Project description:We aimed to investigate genome wide DNA methylation changes in human colon organoids in which the BRAF-V600E mutation was introduced by means of CRISPR genome editing and in BRAF-wildtype human colon cancer organoids. DNA methylation analysis was performed using the Infinium Methylation EPIC beadchip at the Pathology department of the UMC Utrecht (The Netherlands).

2023-12-20 | E-MTAB-13290 | biostudies-arrayexpress

RNA-seq of BRAF-V600E_mutated and BRAF-V600E_corrected colon cancer organoids

Project description:We aimed to investigate transcriptional changes in human colon cancer organoids with the BRAF-V600E mutation and in human colon cancer organoids in which the BRAF-V600E mutation was corrected by means of CRISPR genome editing. RNAseq was performed at USEQ at the UMC Utrecht (The Netherlands).

2024-02-21 | E-MTAB-13806 | biostudies-arrayexpress

Illumina Infinium HumanMethylation EPIC beadchip profiling of BRAF-V600E_mutated and BRAF-V600E_corrected colon cancer organoids

Project description:We aimed to investigate genome wide DNA methylation changes in human colon cancer organoids with the BRAF-V600E mutation and in human colon cancer organoids in which the BRAF-V600E mutation was corrected by means of CRISPR genome editing. DNA methylation analysis was performed using the Infinium Methylation EPIC beadchip at the Pathology department of the UMC Utrecht (The Netherlands).

2023-12-20 | E-MTAB-13283 | biostudies-arrayexpress

RNA-seq of BRAF-V600E_mutated and BRAF-V600E_corrected colon cancer organoids_advanced starvation

2024-08-23 | E-MTAB-14298 | biostudies-arrayexpress

RNA-seq of BRAF-V600E_mutated and BRAF-V600E_corrected colon cancer organoids

Project description:RNA-seq of BRAF-V600E_mutated and BRAF-V600E_corrected colon cancer organoids

| PRJEB72708 | ENA

Expression of BRAF inhibitor resistant colon cancer lines

Project description:Colon cancer cell lines with partial sensitivity to the BRAF inhibitor PLX4720 were grown in increasing concentration of the drug to develop acquired resistance. Gene expression was performed for comparison of the resistant clones to the parental lines. Colon cancer cell lines with partial sensitivity to the BRAF inhibitor PLX4720 were grown in increasing concentration of the drug to develop acquired resistance. Gene expression was performed for comparison of the resistant clones to the parental lines.

2012-09-15 | E-GEOD-34299 | biostudies-arrayexpress

Transcriptome-wide in vitro effects of aspirin on patient-derived normal colon organoids

Project description:Here, we used bulk RNA-seq data derived from healthy colon organoids (un)exposed to aspirin. Through the use of external single cell RNA-seq data, we estimate changes in cell composition. We extend this analysis by controlling for cell composition and performing WGCNA to identify modules of co-expression differentially affected by aspirin treatment in colon organoids.

2021-01-31 | GSE163282 | GEO

DNA methylation analysis of normal colon organoids from familial adenomatous polyposis patients reveals novel insight into colon cancer development

Project description:To develop a better understanding of the biology underlying risk for CRC posed by germ line APC mutations we performed DNA methylation analysis of colon organoids derived from normal-appearing colons of FAP subjects (n=7) and matched healthy individuals (n=16). We identified a large number (n=358) of differentially methylated regions (DMRs) between colon organoids of FAP and healthy subjects, many of which were also identified in a comparison of tumor and normal adjacent tissue (NAT) in two independent, sporadic CRC tumor cohorts.

2022-10-13 | GSE197646 | GEO

RNA-seq of BRAF-V600E_mutated and BRAF-V600E_corrected colon cancer organoids_advanced starvation

Project description:RNA-seq of BRAF-V600E_mutated and BRAF-V600E_corrected colon cancer organoids_advanced starvation

| PRJEB78426 | ENA