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ABSTRACT: "Expression profiling on the mouse E11.5 rostral telencephalon of Emx1Cre Gli3 conditional mutants"

PROVIDER: PRJEB7343 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR632097_1.fastq.gz	Fastqsanger.gz
	ERR632097_2.fastq.gz	Fastqsanger.gz
	ERR632098_1.fastq.gz	Fastqsanger.gz
	ERR632098_2.fastq.gz	Fastqsanger.gz
	ERR632099_1.fastq.gz	Fastqsanger.gz

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Project description:Expression profiling on the mouse E12.5 rostral telencephalon of Emx1Cre Gli3 conditional mutants

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The BAF complex does not mediate GLI repression (Gli3 null Cut&RUN)

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Project description:The Otx2 homeobox transcription factor is essential for gastrulation and early neural development. We generated Otx2 conditional knockout (cKO) mice to investigate its roles in telencephalon development after E9.0. We conducted transcriptional profiling and in situ hybridization to identify genes de-regulated in Otx2 cKO ventral forebrain. In parallel, we used ChIP-seq to identify enhancer elements, OTX2 binding motif, and which de-regulated genes are likely direct targets of Otx2 transcriptional regulation. We found that Otx2 was essential in septum specification; regulation of Fgf signaling in the rostral telencephalon; and medial ganglionic eminence (MGE) patterning, neurogenesis, and oligodendrogenesis. Within the MGE, Otx2 was required for ventral but not dorsal identity; this is the first demonstration of a transcription factor that contributes to regional patterning within the MGE. Microdissected subpallium (septum, MGE, and LGE ) from wildtype E12.5 CD-1 embryos was used in three independentanti-OTX2 ChIP-seq experiments.

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