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Mechanism of action of the novel small molecule IMP-1700 against Staphylococcus aureus

ABSTRACT: Staphylococcus aureus passaged with IMP-1700

PROVIDER: PRJEB73806 | ENA |

REPOSITORIES: ENA

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Mechanism of action of the novel small molecule IMP-1700 against Staphylococcus aureus

Project description:WGS of S. aureus isolates serially passaged with either IMP-1700 or zoliflodicin

| PRJEB75336 | ENA

E. coli imp fabI(G93V) Mutant Cells: Control (E. coli imp fabI(G93V) ) vs. NTG-treated E. coli imp fabI(G93V)

Project description:Transcriptional profiling of NTG-treated E. coli imp fabI(G93V) cells compared to control cells (E. coli imp fabI(G93V) ) in the absence or presence of sub-lethal concentration of triclosan.

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Project description:S. aureus SH1000 isolates passaged with zoliflodicin exhibit altered susceptibility to IMP-1700

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Project description:IMP-3 Promotes Migration and Invasion of Melanoma Cells by Modulating the Expression of HMGA2 and Predicts Poor Prognosis in Melanoma

2014-10-23 | GSE62574 | GEO

MeWo/IMP-3 v.s. MeWo/vec

Project description:IMP-3 Promotes Migration and Invasion of Melanoma Cells by Modulating the Expression of HMGA2 and Predicts Poor Prognosis in Melanoma Two-condition experiment,MeWo/IMP-3 v.s. MeWo/vec. Biological replicates: 2 control replicates, 2 transfected replicates.

2014-10-23 | E-GEOD-62574 | biostudies-arrayexpress

Drosophila Imp iCLIP identifies an RNA assemblage co-ordinating F-actin formation

Project description:In this study, we employed a combination of RIP-seq and short- and long-wave iCLIP technologies to identify transcripts associated with cytoplasmic RNPs containing the RNA-binding protein Drosophila Imp. We also made a Imp knockdown vs luciferase control experiment.

2015-05-27 | GSE62997 | GEO

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Project description:IMP-producing Pseudomonas aeruginosa

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RNAi knock down of RNA binding IMP proteins in human epithelial (HeLa) cells

Project description:To identify factors and pathways regulated by IMP proteins and obtain leads to the mechanism behind the phenotypic changes, we compared the gene expression profiles of IMP siRNA treated cells with mock treated cells. Triplicate gene expression profiles were generated from both the IMP(1,3)A and IMP(1,3)B siRNA sets and were compared to the mock transfected cells. cRNA was hybridized to Affymetrix human U133A arrays.

2006-09-30 | E-MEXP-548 | biostudies-arrayexpress

Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

Project description:The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by known extrinsic signals. However, the intrinsic mechanisms that control the characteristic proliferation rates of individual neural stem cells are unknown. Here, we show that the size and division rates of Drosophila neural stem cells (neuroblasts) are controlled by the highly conserved RNA binding protein Imp (IGF2BP), via one of its top binding targets in the brain, myc mRNA. We show that Imp stabilises myc mRNA leading to increased Myc protein levels, larger neuroblasts, and faster division rates. Declining Imp levels throughout development limit myc mRNA stability to restrain neuroblast growth and division, while heterogeneous Imp expression correlates with myc mRNA stability between individual neuroblasts in the brain. We propose that Imp-dependent regulation of myc mRNA stability fine-tunes individual neural stem cell proliferation rates.

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Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.

Project description:Inhibitors of triacylglycerol (TG) synthesis have been developed to treat metabolism-related diseases, but we know little about their mechanisms of action. Here, we report cryo-EM structures of the TG-synthesis enzyme acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a membrane bound O-acyltransferase (MBOAT), in complex with two different inhibitors, T863 and DGAT1IN1. Each inhibitor binds DGAT1's fatty acyl-CoA substrate binding tunnel that opens to the cytoplasmic side of the ER. T863 blocks access to the tunnel entrance, whereas DGAT1IN1 extends further into the enzyme, with an amide group interacting with more deeply buried catalytic residues. A survey of DGAT1 inhibitors revealed that this amide group may serve as a common pharmacophore for inhibition of MBOATs. The inhibitors were minimally active against the related MBOAT acyl-CoA:cholesterol acyltransferase 1 (ACAT1), yet a single-residue mutation sensitized ACAT1 for inhibition. Collectively, our studies provide a structural foundation for developing DGAT1 and other MBOAT inhibitors.

| S-EPMC10227072 | biostudies-literature

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