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DdHypPerf

ABSTRACT: Hypericum perforatum

PROVIDER: PRJEB76363 | ENA |

REPOSITORIES: ENA

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Dataset's files

Source:

			Action	DRS
	ERR13248960_1.fastq.gz	Fastqsanger.gz
	ERR13248960_2.fastq.gz	Fastqsanger.gz
	ERR13248961_1.fastq.gz	Fastqsanger.gz
	ERR13248961_2.fastq.gz	Fastqsanger.gz
	ERR13248962_1.fastq.gz	Fastqsanger.gz

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Project description:Hypericum perforatum extracts have been used as dietary supplements to treat conditions including mild-moderate depression and inflammation. A group of four bioactive constituents were identified from an active fraction of the extract. In order to identify the mechanism for the potential anti-inflammatory activity of the identified compounds, we used Affymatrix microarray to study the gene expression profile impacteded by these compounds, as well as the active fraction in LPS-stimulated mouse macrophages. We treated RAW264.7 mouse macrophages with DMSO control, active fraction from Hypericum perforaum extract, and a combination of the 4 putative bioactive compounds, called the 4-component system, all with and without LPS induction. A total of six treatment combinations were included in the final gene expression analysis using microarray.

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Project description:Hypericum perforatum Raw sequence reads

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