Project description:The Wnt/β-catenin signaling pathway is a critical regulator of development and stem cell maintenance. Mounting evidence suggests that the context-specific outcome of Wnt signaling is determined by the collaborative action of multiple transcription factors, including members of the highly conserved forkhead box (FOX) protein family. The contribution of FOX transcription factors to Wnt signaling has not been investigated in a systemic manner. Here, by combining β-catenin reporter assays with Wnt pathway-focused qPCR arrays and proximity proteomics of selected FOX family members, we determine that most FOX proteins are involved in the regulation of Wnt pathway activity and the expression of Wnt ligands and target genes. We conclude that FOX proteins are common regulators of the Wnt/β-catenin pathway that may control the outcome of Wnt signaling in a tissue-specific manner.

2023-04-19 | PXD038811 | Pride

Polar Fox Lagoon sediment

Project description:Polar Fox Lagoon sediment Metagenome

| PRJNA821074 | ENA

STEC from Swedish cervids

Project description:STEC from Swedish cervids

| PRJEB53334 | ENA

Metagenomes of Swedish lakes

Project description:Metagenomes of Swedish lakes

| PRJEB54817 | ENA

Swedish STPs

Project description:Metagenomic characterization of three Swedish sewage treatment plants