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Impact of commercial gut health interventions on caecal metagenome and broiler performance

ABSTRACT: Impact of commercial gut health interventions on caecal metagenome and broiler performance

PROVIDER: PRJEB79352 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR13583800_1.fastq.gz	Fastqsanger.gz
	ERR13583800_2.fastq.gz	Fastqsanger.gz
	ERR13583900_1.fastq.gz	Fastqsanger.gz
	ERR13583900_2.fastq.gz	Fastqsanger.gz
	ERR13583801_1.fastq.gz	Fastqsanger.gz

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Project description:Campylobacter is the most frequent foodborne zoonotic bacteria worldwide, with chicken meat being overwhelmingly the most important reservoir for human infections. Control measures implemented at the farm level (i.e., biosecurity or vaccination), which have been successfully applied to limit other pathogens, such as Salmonella, have not been effective in reducing Campylobacter occurrence. Thus, new approaches are needed to fully understand the ecological interactions of Campylobacter with host animals to effectively comprehend its epidemiology. The objective of this study was to analyse longitudinally the gut microbiota composition of Campylobacter-infected and non-infected farms to identify any difference that could potentially be indicative of gut colonization by Campylobacter spp. Differences in the colonization rate and timing were observed at the farms that became positive for Campylobacter jejuni over the investigated time points, even though in positive tests, the occurrence of Campylobacter jejuni gut colonization was not observed before the second week of the life of the birds. Significant differences were observed in the abundances of specific bacterial taxa between the microbiota of individuals belonging to farms that became Campylobacter positive during the study and those who remained negative with particular reference to Bacteroidales and Clostridiales, respectively. Moreover, Campylobacter colonization dramatically influenced the microbiota richness, although to a different extent depending on the infection timing. Finally, a key role of Faecalibacterium and Lactobacillus genera on the Campylobacter microbial network was observed. Understanding the ecology of the Campylobacter interaction with host microbiota during infection could support novel approaches for broiler microbial barrier restoration. Therefore, evidence obtained through this study can be used to identify options to reduce the incidence of infection at a primary production level based on the targeted influence of the intestinal microbiota, thus helping develop new control strategies in order to mitigate the risk of human exposure to Campylobacter by chicken meat consumption.

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Impact of commercial gut health interventions on caecal metagenome and broiler performance

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