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Genome-wide maps of H3K4me1 in Mycobacterium tuberculosis H37Rv-infected macrophages

ABSTRACT: Genome-wide maps of H3K4me1 in Mycobacterium tuberculosis H37Rv-infected macrophages

PROVIDER: PRJEB8059 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR706874_1.fastq.gz	Fastqsanger.gz
	ERR706874_2.fastq.gz	Fastqsanger.gz
	ERR706875_1.fastq.gz	Fastqsanger.gz
	ERR706875_2.fastq.gz	Fastqsanger.gz
	ERR706876_1.fastq.gz	Fastqsanger.gz

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Genome-wide maps of H3K4me1 in Mycobacterium tuberculosis H37Rv-infected macrophages

Project description:Host macrophage transcriptional responses to intracellular pathogens remain poorly characterized. We screened transcriptional enhancers engaged in response to M. tuberculosis (Mtb) infection by ChIPseq analysis of histone H3 lysine 4 monomethylation (H3K4me1). De novo monomethylation during infection was associated with genes implicated in host defense and apoptosis. These regions were enriched for binding sites for ETS transcription factor family members and response elements for nuclear receptors, including liver X receptors (LXRs) and peroxisomal proliferator activated receptors (PPARs), many of which were encompassed by transposable elements. LXRa expression was strongly induced by infection, whereas that of PPARs was unaffected. LXR DNA binding and NCoR corepressor recruitment increased proportionately in infected cells but coactivator association was unchanged, consistent with a lack of induction of endogenous agonists. However, treatment of infected cells with LXR agonist T0901317 strongly increased coactivator recruitment and induced a gene expression program characterized by enhanced innate immune signaling and lipid metabolism. Remarkably, T0901317 treatment selectively induced apoptosis in infected macrophages, and was accompanied by Mtb death, reducing mycobacterial burden 18-fold relative to vehicle 5d after infection. These studies define macrophage transcriptional responses to Mtb infection, and suggest that tissue-specific LXRa agonists may be efficacious in clinical management of tuberculosis.

2015-10-15 | E-MTAB-3192 | biostudies-arrayexpress

Mycobacterium tuberulosis H37Rv strains: Control vs. Osthole.

2011-09-14 | GSE32076 | GEO

Mycobacterium tuberculosis H37Rv strains: Control vs. Linezolid.

Project description:Transcriptional profiling of Mycobacterium tuberculosis H37Rv strains comparing control DMSO treated strains with Linezolid treated strains. Goal was to determine the effects of Linezolid against Mycobacterium tuberculosis H37Rv strains.

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Mycobacterium tuberculosis H37Rv strains: Control vs. Lupulone

2011-08-30 | GSE31732 | GEO

Mycobacterium tuberulosis H37Rv strains: Control vs. Plumbagin

Project description:Transcriptional profiling of Mycobacterium tuberculosis H37Rv strains comparing control DMSO treated strains with Plumbagin treated strains. Goal was to determine the effects of Plumbagin against Mycobacterium tuberculosis H37Rv strains.

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Mycobacterium tuberulosis H37Rv strains: Control vs. Chelerythrine

Project description:Transcriptional profiling of Mycobacterium tuberculosis H37Rv strains comparing control DMSO treated strains with chelerythrine treated strains. Goal was to determine the effects of chelerythrine against Mycobacterium tuberculosis H37Rv strains.

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Mycobacterium tuberulosis H37Rv strains: Control vs. 5-chloro-8-hydroxyquinoline

Project description:Transcriptional profiling of Mycobacterium tuberculosis H37Rv strains comparing control DMSO treated strains with 5-chloro-8-hydroxyquinoline treated strains. Goal was to determine the effects of 5-chloro-8-hydroxyquinoline against Mycobacterium tuberculosis H37Rv strains.

2011-09-16 | GSE32157 | GEO

M. tuberculosis H37Rv: mutant expressing foreign peptide SL3 Vs control H37Rv

Project description:Transcriptional profiling of M.tb H37Rv cells comparing control wild type H37Rv with H37Rv cells electroporated with constitutive expression plasmid pVV16 expressing ESAT-6 binding peptide SL3. The expression of SL3 makes H37Rv less virulent during ex vivo and BalB/c mice infections, sequesters ESAT-6 inside M.tb cells and cause severe defects in mycobacterial morphology. Goal was to determine the effects of SL3 expression on global H37Rv gene expression. Two color Experiment,Organism: Mycobacterium Tuberculosis, ilife Discoveries designed Custom Mycobacterium tuberculosis on 8x15k GE Microarray. Two-condition experiment, H37Rv vs. H37Rv/SL3. Biological replicates: 2 biological control H37RV replicates labelled with Cy3, 2 SL3 biological expressing replicates labelled with Cy5.

2014-04-10 | E-GEOD-51085 | biostudies-arrayexpress

Mycobacterium tuberulosis H37Rv strains: Control vs. Osthole.

Project description:Transcriptional profiling of Mycobacterium tuberculosis H37Rv strains comparing control DMSO treated strains with Osthole treated strains. Goal was to determine the effects of Osthole against Mycobacterium tuberculosis H37Rv strains. Two-condition experiment,control DMSO treated strains vs. Osthole treated strains. Biological replicates: 2 control replicates, 2 Osthole replicates.

2011-09-13 | E-GEOD-32076 | biostudies-arrayexpress

Mycobacterium tuberculosis H37Rv strains: Control vs. Lupulone

Project description:Transcriptional profiling of Mycobacterium tuberculosis H37Rv strains comparing control DMSO treated strains with Lupulone treated strains. Goal was to determine the effects of Lupulone against Mycobacterium tuberculosis H37Rv strains. Two-condition experiment,control DMSO treated strains vs. Lupulone treated strains. Biological replicates: 2 control replicates, 2 Lupulone replicates.

2011-08-29 | E-GEOD-31732 | biostudies-arrayexpress

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