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Transcriptome analysis of corpora lutea in domestic cats (Felis catus)

ABSTRACT: Transcriptome analysis of corpora lutea in domestic cats (Felis catus) reveals strong life cycle differences in gene expression for a variety of hormones, hormone receptors and regulators

PROVIDER: PRJEB82722 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR13999619_1.fastq.gz	Fastqsanger.gz
	ERR13999619_2.fastq.gz	Fastqsanger.gz
	ERR13999621_1.fastq.gz	Fastqsanger.gz
	ERR13999621_2.fastq.gz	Fastqsanger.gz
	ERR13999624_1.fastq.gz	Fastqsanger.gz

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A Mutation in LTBP2 Causes Congenital Glaucoma in Domestic Cats (Felis catus)

Project description:The glaucomas are a group of diseases characterized by optic nerve damage that together represent a leading cause of blindness in the human population and in domestic animals. Here we report a mutation in LTBP2 that causes primary congenital glaucoma (PCG) in domestic cats. We identified a spontaneous form of PCG in cats and established a breeding colony segregating for PCG consistent with fully penetrant, autosomal recessive inheritance of the trait. Elevated intraocular pressure, globe enlargement and elongated ciliary processes were consistently observed in all affected cats by 8 weeks of age. Varying degrees of optic nerve damage resulted by 6 months of age. Although subtle lens zonular instability was a common feature in this cohort, pronounced ectopia lentis was identified in less than 10% of cats examined. Thus, glaucoma in this pedigree is attributed to histologically confirmed arrest in the early post-natal development of the aqueous humor outflow pathways in the anterior segment of the eyes of affected animals. Using a candidate gene approach, significant linage was established on cat chromosome B3 (LOD 18.38, q = 0.00) using tightly linked short tandem repeat (STR) loci to the candidate gene, LTBP2. A 4 base-pair insertion was identified in exon 8 of LTBP2 in affected individuals that generates a frame shift that completely alters the downstream open reading frame and eliminates functional domains. Thus, we describe the first spontaneous and highly penetrant non-rodent model of PCG, identifying a valuable animal model for primary glaucoma that closely resembles the human disease providing valuable insights into mechanisms underlying the disease and a valuable animal model for testing therapies.

2016-05-01 | GSE73263 | GEO

Felis catus breed:Domestic shorthair

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Project description:A Mutation in LTBP2 Causes Congenital Glaucoma in Domestic Cats (Felis catus)

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Felis catus

Project description:Felis catus genome sequencing

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Felis catus strain:domestic short hair

Project description:Felis catus strain:domestic short hair Transcriptome or Gene expression

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Expression data from corpora lutea from cows supplemented with different forms of selenium (Se)

Project description:The goal of this study was to test the hypothesis that sodium selenite (ISe) vs. a 1:1 blend (MIX) of ISe and SEL-PLEX in a basal vitamin-mineral (VM) mix would differentially alter corpora lutea transcriptome profiles in non-lactating beef cows. Predominately-Angus cows were randomly selected from herds of fall-calving cows consuming VM mixes that contained 35 ppm Se as ISe and MIX forms. Cows were depleted of Se for 45 d followed by a 45 d repletion period with ISe to bring all cows to Se adequate status. Cows were then randomly assigned to treatment (ISe, n=5; or MIX, n=5) with treatments administered for at least 90 days using in-pasture Calan gates. Corpora lutea samples were then collected on Day 7 post-estrus and examined for changes in global expression patterns by microarray analysis.

2022-06-01 | GSE190092 | GEO

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