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HepG2 cells exposed to Benzo[a]pyrene for 6,12,18,24,36 and 48h.

ABSTRACT: HepG2 cells exposed to Benzo[a]pyrene for 6,12,18,24,36 and 48h.

PROVIDER: PRJEB8274 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR738399.fastq.gz	Fastqsanger.gz
	ERR738400.fastq.gz	Fastqsanger.gz
	ERR738401.fastq.gz	Fastqsanger.gz
	ERR738402.fastq.gz	Fastqsanger.gz
	ERR738403.fastq.gz	Fastqsanger.gz

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HepG2 cells exposed to Benzo[a]pyrene for 6,12,18,24,36 and 48h.

Project description:HepG2 cells (human liver hepatocarcinoma) were exposed for 6 different time points (6,12,18,24,36 and 48h) to Benzo[a]pyrene (BaP) in duplicate.

2015-01-25 | E-MTAB-3251 | biostudies-arrayexpress

Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells

Project description:This SuperSeries is composed of the following subset Series: GSE36242: Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (RNA-Seq) GSE36243: Transcriptomic response to benzo[a]pyrene treatment in HepG2 cells (Affymetrix) Refer to individual Series

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ribo-depleted RNA-Seq of HepG2 cells exposed to Benzo[a]pyrene for 6,12,18,24,36 and 48h.

Project description:ribo-depleted RNA-Seq of HepG2 cells exposed to Benzo[a]pyrene for 6,12,18,24,36 and 48h.

| PRJEB8436 | ENA

ribo-depleted RNA-Seq of human HepG2 cells exposed to Benzo[a]pyrene for 6, 12, 18, 24, 36 and 48 hours

Project description:HepG2 cells (human liver hepatocarcinoma) were exposed for 6 different time points (6,12,18,24,36 and 48h) to Benzo[a]pyrene (BaP) in duplicate. Total RNAs were ribo-depleted and sequenced on an Illumina Hiseq2000 in pair-end 100 bp reads. One of the duplicates for BaP-treated sample at the 24 hour time point was found to have a minor fastq file integrity issue and was removed from this data set as a precaution.

2015-08-02 | E-MTAB-3292 | biostudies-arrayexpress

benzo(a)pyrene_MCF7_HepG2

Project description:MCF-7 and HepG2 cells were exposed to a range of concentrations of benzo(a)pyrene or benzo(e)pyrene (0-5 uM) for up to 48 h and gene expression analysis performed. Keywords: dose response

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Acute hepatic transcriptional response in male mice following oral exposure to benzo(a)pyrene

Project description:Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male B6C3F1 mice were exposed to four doses of benzo(a)pyrene or vehicle control for three days and sacrificed 4 or 24 hours after the final exposure.

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Sub-chronic forestomach transcriptional response in adult male MutaTMMouse following oral exposure to benzo(a)pyrene

Project description:Benzo(a)pyrene is a well-established human carcinogen in humans and rodents. In the present study, we sought to determine the dose- and time-dependent changes in gene expression upon oral exposure to benzo(a)pyrene. Adult male MutaTMMouse were exposed to three doses of benzo(a)pyrene or vehicle control (olive oil) for 28 days and sacrificed three days after the final exposure.

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Cytochrome P450 Monooxygenase Mediated Metabolic Utilization of Benzo(a)pyrene by Fungi

Project description:Soil dwelling Aspergillus fungi possess the versatile metabolic capability to utilize complex organic compounds which are toxic to humans, yet the mechanisms they employ remain largely unknown. Benzo(a)pyrene is a common carcinogenic contaminant, posing a significant concern for human health. Here, we report that Aspergillus fungi can degrade benzo(a)pyrene effectively. In Aspergillus nidulans, exposure to benzo(a)pyrene results in transcriptomic and metabolic changes associated with cellular growth and energy generation, implying that the fungus utilizes benzo(a)pyrene as a food. Importantly, we identify and characterize the conserved bapA gene encoding a cytochrome P450 monooxygenase that exerts the first step in the degradation of benzo(a)pyrene. We further demonstrate that the fungal NF-κB-type global regulators VeA and VelB are required for benzo(a)pyrene degradation in A. nidulans, which occurs through expression control of bapA in response to nutrient limitation. Our study illuminates fundamental knowledge of fungal benzo(a)pyrene metabolism and provides novel insights into enhancing bioremediation potential.

2018-07-10 | GSE116804 | GEO

Glutathione S-transferase induction after exposure to benzo[a]pyrene

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Transcriptome responses in copepods Calanus glacialis exposed to phenanthrene and benzo[a]pyrene

Project description:The arctic ecosystems are increasingly exposed to pollution particularly from offshore petroleum extraction-related activities. The objective of the study is to map transcriptome responses in copepods of the arctic region in response to PAHs phenanthrene (Phe) and benzo[a]pyrene (BaP) found in crude-oil contaminants.

2021-10-01 | E-MTAB-10911 | biostudies-arrayexpress

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