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Growth Potential and Community Dynamics of Non-Tuberculous Mycobacteria in Chloraminated Secondary Water Supply Systems

ABSTRACT: This study provides valuable insights into the growth potential and source contribution of NTM community along water transportation in choloramineted secondary water supply systems SWSSs.

PROVIDER: PRJEB83991 | ENA |

REPOSITORIES: ENA

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Growth Potential and Community Dynamics of Non-Tuberculous Mycobacteria in Chloraminated Secondary Water Supply Systems

Project description:Growth Potential and Community Dynamics of Non-Tuberculous Mycobacteria in Chloraminated Secondary Water Supply Systems

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Mucosal exposure to non-tuberculous mycobacteria elicits B-cell mediated protection against pulmonary tuberculosis

Project description:Bacille Calmette Guerin (BCG) is the only licensed vaccine against Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease. However, BCG has limited efficacy, necessitating the development of better vaccines. Non-tuberculous mycobacteria (NTM), a distinct lineage from Mtb, are opportunistic pathogens present in the environment. TB endemic countries experience higher exposure to NTM, but previous studies have not elucidated the relationship between NTM exposure and BCG efficacy. Therefore, we developed a mouse model (BCG+NTM) that mimics human BCG vaccination at an early stage and continuous NTM exposure via the oral route, including during TB infection. Our results show that BCG+NTM mice had improved protection against pulmonary TB correlating with increased pulmonary influx of B-cells, higher titers of anti-Mtb IgA and IgG antibodies in serum and airways, compared to mice vaccinated with BCG alone. Notably, the lungs of BCG+NTM mice developed B-cell aggregates expressing markers of germinal center formation as determined by spatial transcriptomics. We conclude a direct correlation between NTM exposure and protection from TB, with B-cells playing a crucial role.

2022-10-23 | GSE203037 | GEO

Specificity of the innate immune responses to different classes of non-tuberculous mycobacteria

Project description:Mycobacterium avium is the most common nontuberculous mycobacterium (NTM) species causing infectious disease. Here, we characterized a M. avium infection model in zebrafish larvae, and compared it to M. marinum infection, a model of tuberculosis. Using RNAseq analysis, we found a distinct transcriptome response in cytokine-cytokine receptor interaction for M. avium and M. marinum infection. In addition, we found substantial differences in gene expression in metabolic pathways, phagosome formation, matrix remodeling, and apoptosis in response to these mycobacterial infections.

2023-01-12 | GSE218892 | GEO

Immunological characteristics of non-tuberculous mycobacterial pulmonary disease

Project description:This study aims to comprehensively investigate the immunological responses associated with non-tuberculous mycobacterial pulmonary disease (NTM-PD). We evaluated immune-related gene expression profiles using nCounter assays on peripheral blood mononuclear cell samples from 18 patients diagnosed with NTM-PD, comparing them with samples from 6 healthy controls.

2025-02-24 | GSE290289 | GEO

Sequencing data novel and rare non-tuberculous mycobacteria CZ and SVK

Project description:novel and rare NTM CZ and SVK

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Nontuberculous mycobacteria

Project description:The NTM Project at the Children's Hospital of Philadelphia

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Secondary Water Supply Systems

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Early responses of Brassica oleracea roots to zinc supply under sufficient and sub-optimal phosphorus supply

Project description:Shoot zinc (Zn) in Brassica oleracea is affected by soil Zn and phosphorus (P) concentrations. Most problematic is the negative impact of P fertilizers on Zn concentrations in crops, which makes balancing yield and mineral quality challenging. To evaluate molecular mechanisms involved in the accumulation of large shoot Zn concentrations regardless of the P supply, two B. oleracea accessions were grown hydroponically for two weeks with different combination of P and Zn supply. Ionome profiling and deep RNA sequencing of roots revealed interactions of P and Zn in planta, without apparent phenotypic effects. In addition, increasing P supply did not reduce tissue Zn concentration. Substantial changes in gene expression in roots of both accessions ensured nutritionally sufficient P and Zn uptake. Numerous genes were differentially expressed after changing Zn or P supply and most of them were unique to only one accession, highlighting different strategies in achieving nutrient sufficiency. Thus, different gene networks responded to the changing P and Zn supply in the two accessions. Additionally, enrichment analysis of gene ontology classes revealed that genes involved in lipid metabolism, response to starvation, and anion transport mechanisms were most responsive to the contrasting P and Zn supply in both accessions. The results agreed with previously studies demonstrating alterations in P transport and phospholipid metabolism in response to reduced P supply. Knowledge of genes responsive to P or Zn supply will help illuminate the interactions between these elements in their uptake and accumulation by plants and might highlight candidate genes for breeding high-yield-high-Zn crops.

2019-03-01 | GSE127467 | GEO

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