Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell RNAseq of immune cells from human palatine tonsils

ABSTRACT: Single cell RNAseq of immune cells from human palatine tonsils

PROVIDER: PRJEB87674 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single cell RNAseq of immune and stromal cells from human palatine tonsils

Project description:Palatine tonsils are secondary lymphoid organs that are strategically positioned in the oropharynx to secure a first line of defense against oral pathogens. Specialized immune-interacting fibroblasts, generally termed fibroblastic reticular cells (FRC), underpin distinct microenvironments within lymphoid organs to compartmentalize and direct the efficient interaction and activation of immune cells. As a particular anatomical property, palatine tonsils harbor a reticular-shaped lymphoepithelium that generates an antigen sampling zone in the crypts. While the histological ultrastructure and the immune cell composition of human palatine tonsils has been elaborated in detail, the molecular identity of the diverse stromal cell compartments including FRC and the specialized lymphoepithelium remains largely unknown. Here, we have employed single cell transcriptomics and extensive flow cytometric analyses to unveil the molecular identity of tonsillar cells and to disentangle the heterogeneity of fibroblast and epithelial cell subsets in palatine tonsils. Our results reveal a remarkable conservation of stromal cell organization and molecularly-defined subsets in infant and adult human palatine tonsils.

2023-03-30 | E-MTAB-11715 | biostudies-arrayexpress

Single cell RNAseq of immune and stromal cells from human palatine tonsils

Project description:Single cell RNAseq of immune and stromal cells from human palatine tonsils

| PRJEB56820 | ENA

Transcription profiling of human CD4 T cell subsets isolated from peripheral blood and palatine tonsils

Project description:Comparatative gene expression analysis for CD4 T cell subsets isolated from peripheral blood and palatine tonsils

2006-07-01 | E-MEXP-750 | biostudies-arrayexpress

Single cell RNAseq reveal covid19 patient immune response

Project description:Single cell RNAseq reveal covid19 patient immune response

| PRJNA646704 | ENA

Single cell RNAseq of immune and stromal cells from human lymph nodes

Project description:Single cell RNAseq of immune and stromal cells from human lymph nodes

| PRJEB52761 | ENA

Single-cell RNAseq of the resident immune cells from Gli1HhipCKO_Tam and Gli1HhipCKO_Oil_Control mice lungs

Project description:To study resident immune cells in Hhip-deleted lungs, we conduct single-cell RNAseq of the resident immune cells from Gli1HhipCKO_Tam and Gli1HhipCKO_Oil_Control mice lungs using 10X genomics scRNAseq technique.

2023-02-13 | GSE206721 | GEO

Single cell RNAseq of immune and stromal cells from human lymph nodes

Project description:B cell-interacting reticular cells (BRC) form transcriptionally and topologically stable immune-interacting microenvironments that direct efficient humoral immunity. While several immune niche factors have been elucidated, the cues sustaining BRC function and topology across activation states remain unclear. Here, we employed single cell RNA-sequencing of human lymph node stromal cells and immune cells to analyse local BRC-immune cell interactions and compare them across SLOs and species from additional datasets. Shared BRC subsets were imprinted by tissue-specific gene signatures, but also expressed functionally convergent niche factors that directed regionalized leukocyte composition. Local BRC-immune cell interactions sustained BRC subset identity via immune cell-provided maturation factors. Bidirectional signalling programs were independent of activation state and mirrored across murine and human tissues. Collectively, our data reveal a conserved set of feedforward BRC-immune cell circuits that sustain topologically-organized, functional niches across inflammatory states, lymphoid organs and species.

2023-03-30 | E-MTAB-11710 | biostudies-arrayexpress

Single-cell multiome analysis of human tonsil B cells

Project description:B cells from tonsils of human donors were extracted for combined RNAseq+ATACseq from the same cell. One sample was prepared separately ("old") and is of lower quality, but still included. It primarily holds ATACseq information.

2023-04-13 | E-MTAB-12632 | biostudies-arrayexpress

Single cell RNAseq provides insight into altered immune cell populations in human fracture nonunions

Project description:Single cell RNAseq provides insight into altered immune cell populations in human fracture nonunions

| PRJNA900553 | ENA

Expression data of centroblasts (CB) and centrocytes (CC) purified from human tonsils

Project description:GEP on Affymetrix U133+2.0 microarrays was performed on 6 centroblasts and 6 paired centrocytes from human tonsils in order to explore CB/CC transition and GC-B cell specific signatures

2019-08-23 | GSE136249 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data