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Effect of INO80 overexpression on gene expression in adult cardiomyocytes (CMs).

ABSTRACT: Effect of INO80 overexpression on gene expression in adult cardiomyocytes (CMs).

PROVIDER: PRJNA1002580 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25532680_1.fastq.gz	Fastqsanger.gz
	SRR25532680_2.fastq.gz	Fastqsanger.gz
	SRR25532681_1.fastq.gz	Fastqsanger.gz
	SRR25532681_2.fastq.gz	Fastqsanger.gz
	SRR25532682_1.fastq.gz	Fastqsanger.gz

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Effect of INO80 overexpression on gene expression in adult cardiomyocytes (CMs).

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Project description:Transcriptional regulatory circuits that drive cardiomyocyte maturation are poorly understood. Human iPS cell-derived cardiomyocytes (hiPSC-CMs) have been shown to have fetal cardiomyocyte features in terms of metabolic gene expression profiles. Here we found that in hiPSC-CMs, overexpression of estrogen-related receptor gamma (ERRg) is sufficient to drive cardiomyocyte metabolic maturation programs including the induction of a number of oxidative mitochondrial metabolic genes.

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Adult ventricular cardiomyocytes

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