Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-Wide Characterization of TAZ Binding Sites in Mammary Epithelial Cells

ABSTRACT: Genome-Wide Characterization of TAZ Binding Sites in Mammary Epithelial Cells

PROVIDER: PRJNA1003030 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25553805_1.fastq.gz	Fastqsanger.gz
	SRR25553805_2.fastq.gz	Fastqsanger.gz
	SRR25553806_1.fastq.gz	Fastqsanger.gz
	SRR25553806_2.fastq.gz	Fastqsanger.gz
	SRR25553807_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (RNA-seq)

Project description:TAZ, one of the key components of Hippo signaling pathway, is a transcription coactivator and plays an important role in cell proliferation, anti-apoptosis, therapeutic resistance, cancer stemness and tumorigenesis. TAZ mediated transcription program through transcription factors, such as TEAD family members. Genome-wide TAZ occupancy is poorly defined. Here, using a tet-inducible TAZ activation in mammary epithelial MCF10A cells, we characterized genome-wide binding sites in different TAZ activation time points. We found vast majority of TAZ binds to distal enhancer and intergenic regions of genes in the early TAZ activation time point and shift to promoter regions in the later TAZ activation time point. We identified three distinctive TAZ binding patterns to its targets. Furthermore, we found TAZ activation results in chromatin architecture alterations. Our studies provide insight of TAZ regulated transcription program in mammary epithelial cells and indicate potential therapeutic targets for breast cancer.

2023-10-16 | GSE240244 | GEO

Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (ChIP-seq)

2023-10-16 | GSE240241 | GEO

Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (ATAC-seq)

2023-10-16 | GSE240237 | GEO

Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (ChIP-seq)

Project description:Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (ChIP-seq)

| PRJNA1003033 | ENA

Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (RNA-seq)

Project description:Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (RNA-seq)

| PRJNA1003036 | ENA

Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (ATAC-seq)

Project description:Genome-wide characterization of TAZ binding sites in mammary epithelial cells in temporary and special manner (ATAC-seq)

| PRJNA1003018 | ENA

Effect of activated TAZ expression on mammary epithelial cells

Project description:Effect of activated TAZ expression on mammary epithelial cells

| PRJNA473583 | ENA

Etv4 and Etv5 binding sites in EpRas mouse mammary gland epithelial cell line [ChIP-seq]

Project description:We searched for roles of Etv4 and Etv5 during EMT through genome-wide analysis of their binding sites in Ras-transformed mammary gland epithelial cells.

2017-04-10 | GSE89618 | GEO