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Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation

ABSTRACT: Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation

PROVIDER: PRJNA1003534 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25573550_1.fastq.gz	Fastqsanger.gz
	SRR25573550_2.fastq.gz	Fastqsanger.gz
	SRR25573551_1.fastq.gz	Fastqsanger.gz
	SRR25573551_2.fastq.gz	Fastqsanger.gz
	SRR25573552_1.fastq.gz	Fastqsanger.gz

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Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation [5mC]

Project description:Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation [5mC]

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Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation [5hmc]

Project description:Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation [5hmc]

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Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation [5hmc]

Project description:Maternal infections have been linked to various neuropsychiatric disorders that may later emerge in offspring. 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) are key DNA modifications but their roles in maternal infection remain to be elucidated. It has been documented that Zika virus (ZIKV) infection during pregnancy leads to structural brain defects such as microcephaly in offspring. However, whether and how offspring exposed to maternal ZIKV infection develop neurocognitive complications remain largely unknown. Here we report that ZIKV infection during mouse pregnancy leads to offspring with depression- and anxiety-like behaviors, which are transmitted to the next generation. Single nucleus RNA sequencing in prefrontal cortex (PFC) of ZIKV offspring mice revealed cell type-specific gene dysregulation associated with neuropsychiatric lesions. Genome-wide 5hmC, 5mC, and transcriptome profiling in ZIKV PFC revealed an overall loss of 5hmC and an increase of 5mC in intragenic regions, associated with transcriptional changes in key functional genes. Gain-of-5hmC regions were mainly located in intergenic transposable elements (TEs) coupled with decreased 5mC and dynamic TE expression. These results provide the first 5hmC study in maternal infection and suggest that maternal ZIKV infection remodels methylome and gene expression in offspring mouse brains, contributing to transgenerational behavior changes.

2023-10-25 | GSE240415 | GEO

Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation [5mC]

2023-10-25 | GSE240413 | GEO

Brain methylome remodeling sustains neuronal activity gene expression in mice exposed to maternal immune activation

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-25 | GSE240417 | GEO

Methylome of Fetal and Maternal Monocytes and Macrophages at the Feto-Maternal Interface

Project description:Maternal and fetal monocytes and tissue macrophages (decidual macrophages, Hofbauer cells) at the feto-maternal interface have different methylome. Paired and balanced design. We compared maternal blood monocytes (MB) vs. cord blood monocytes (CB), maternal blood monocytes (MB) vs. decidual macrophages (Deci), cord blood monocytes (CB) vs placental macrophages (villi) and decidual macrophages (Deci) vs. placental macrophages (villi).

2011-11-15 | E-GEOD-31680 | biostudies-arrayexpress

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Project description:Maternal and fetal monocytes and tissue macrophages (decidual macrophages, Hofbauer cells) at the feto-maternal interface have different methylome.

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Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation.

Project description:How early life experience is translated into storable epigenetic information leading to behavioral changes remains poorly understood. Here we found that Zika virus (ZIKV) induced-maternal immune activation (MIA) imparts offspring with anxiety- and depression-like behavior. By integrating bulk and single-nucleus RNA sequencing (snRNA-seq) with genome-wide 5hmC (5-hydroxymethylcytosine) profiling and 5mC (5-methylcytosine) profiling in prefrontal cortex (PFC) of ZIKV-affected male offspring mice, we revealed an overall loss of 5hmC and an increase of 5mC levels in intragenic regions, associated with transcriptional changes in neuropsychiatric disorder-related genes. In contrast to their rapid initiation and inactivation in normal conditions, immediate-early genes (IEGs) remain a sustained upregulation with enriched expression in excitatory neurons, which is coupled with increased 5hmC and decreased 5mC levels of IEGs in ZIKV-affected male offspring. Thus, MIA induces maladaptive methylome remodeling in brain and selectively regulates neuronal activity gene methylation linking to emotional behavioral abnormalities in offspring.

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Project description:We sought to characterize methylome remodeling during regional metastasis. We profiled the DNA methylome (n=44) and transcriptome (n=36) of matched primary breast tumors and regional metastases.

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Methylome remodeling in regional breast cancer metastasis

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