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Gene expression profile at single cell level of trigeminal ganglion non-neuronal cells

ABSTRACT: Gene expression profile at single cell level of trigeminal ganglion non-neuronal cells

PROVIDER: PRJNA1003788 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25581658.fastq.gz	Fastqsanger.gz
	SRR25581659.fastq.gz	Fastqsanger.gz
	SRR25581660.fastq.gz	Fastqsanger.gz
	SRR25581661.fastq.gz	Fastqsanger.gz
	SRR25581662.fastq.gz	Fastqsanger.gz

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Gene expression profile at single cell level of trigeminal ganglion non-neuronal cells

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Project description:Orofacial inflammation could lead to transcriptional alterations in the trigeminal ganglion (TG). In this study, we performed single-cell RNA-sequencing (scRNA-seq) analysis of mouse TG to identify all cell types and profile transcriptomic alterations of TG cells under inflammatory conditions. A total of 7 types of cells including endothelial cells, fibroblasts, glial cells, granulocytes, lymphocytes, monocyte-macrophages and several subtypes of neurons were identified. In addition, we performed annotation of neuronal subtypes and differential gene expression analysis among TG neurons, identifying several differential genes involved in pain modulation such as Scn10a, Zbtb20 and Runx1. Collectively, our study revealed the heterogeneity of TG cells and diverse neuronal transcriptomic responses to orofacial inflammation, which aids in the development of novel therapeutics for orofacial inflammatory pain.

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RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

Project description:RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

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Project description:The epigenetic roles in trigeminal neuralgia (TN) still remain unclear. H3K9ac alteration in neuralgia is obscure and controversy. In this study, we established TN rat model via chronic compression, and further treated with 100 mg/kg/d carbamazepine (CBZ). RNA-seq were conducted to investigate the transcriptional profilings in control, TN and TN+CBZ.

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