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ABSTRACT: Ang II-induced abdominal aortic aneurysm

PROVIDER: PRJNA1004189 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25597336.fastq.gz	Fastqsanger.gz
	SRR25597337.fastq.gz	Fastqsanger.gz
	SRR25597338.fastq.gz	Fastqsanger.gz
	SRR25597339.fastq.gz	Fastqsanger.gz
	SRR25597340.fastq.gz	Fastqsanger.gz

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RNA-sequence analysis of mouse AAA samples obtained from ApoE-/- and ApoE-/-Nur77-/- mice induced by Ang II

Project description:We report the transcriptomic analysis of RNA-seq of abdominal aortas isolated from ApoE-/- and ApoE-/-Nur77-/- mice mice exposed to Ang II to uncover the mechanisms underlying the undefined role of Nur77 in abdominal aortic aneurysm (AAA)

2021-05-21 | GSE174768 | GEO

CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development

Project description:Vascular smooth muscle cell (VSMC) phenotypic switching is widely recognized as a key mechanism responsible for the pathogenesis of several aortic diseases such as aortic aneurysm. Cellular communication network factor 2 (CCN2), often upregulated in human pathologies and animal disease models, exerts a myriad of context-dependent biological functions. However, current understanding of the role of SMC-CCN2 in SMC phenotypic switching and its function in the pathology of abdominal aortic aneurysm (AAA) is lacking. Here we report the effect of SMC-restricted CCN2 deficiency of hypercholesterolemic mice on gene expression in infrarenal aorta with or without angiotensin II (Ang II)-infusion.

2023-03-02 | GSE221399 | GEO

AAA pathology in ApoE and CD57BL/6J mice

Project description:we analyzed proteomics data from ApoE-/- and CD57BL/6J mouse models of Ang II-induced AAA and control mice, which were analyzed abdominal aortic tissues by LC–MS/MS.

2022-05-24 | PXD034043 |

An intersegmental single-cell profile reveals aortic heterogeneity [AAA]

Project description:According to the new scRNA-seq data after batch correction, we obtained 22, 975 cells totally isolated from aortic tissues of three groups including healthy abdominal aorta group (AA group), Ang II+ DMSO group (D_A group) and Ang II+ Inhibitor group (IN_A group)

2022-05-02 | GSE191226 | GEO

Angiotensin II induced aneurysms in male ApoE mice

Project description:In this study we used microarrays to examine relative genes expression within the aorta of ApoE-/- infused with angiotensin II in relation to aneurysm formation. Infusion of angiotensin II induces aortic dilatation particularly of the suprarenal aorta in ApoE-/- mice. Based on studies carried out in our and other laboratories the response to angiotensin II is variable, with some mice developing large aneurysms but other animals appearing resistant to aneurysm formation with aortic diameters similar to that of saline controls. We compared RNA expression from whole aortas of 17 week old male ApoE-/- mice exposed to angiotensin II (1.44 Âµg/kg/min) for 4 weeks where there was clear evidence of aortic aneurysm formation (n=5) with that of mice failing to develop aneurysms (n=7) and those exposed to saline infusion (n=6). AAA was defined as diameter of suprarenal aorta greated than 1.5mm measured on photographs of aortas at necroscopy. Keywords: Disease state analysis 18 samples analysed, AAA (n=5), no AAA (n=7), saline (n=6). AAA - abdominal aortic aneurysm

2010-06-24 | E-GEOD-12591 | biostudies-arrayexpress

Effect of macrophage SNO-Septin2 in aortic aneurysm development

Project description:We analyzed differentially expressed genes in aortas from Apoe-/- mice that received Apoe-/- bone marrow or Apoe-/-Sept2C111A bone marrow and were infused with Ang II for 28 days to explore the mechanisms of macrophage SNO-Septin2 in aortic aneurysm development.

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Project description:abdominal aortic aneurysm metagenome

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Functional expression of melanocortin 4 receptor in monocytes to suppress aortic aneurysm and atherosclerosis in mice

Project description:Melanocortin-4 receptor (MC4R) mediates most anorectic leptin response effects to an agonist, α-melanocyte-stimulating hormone (α-MSH). MC4R mutations are considered to be the main cause of monogenetic obesity in humans. It has been reported that the activity loss of MC4R gene increases body mass index and cardiovascular event risk in humans. This study aimed to investigate our hypothesis that MC4R signaling directly modulates vascular functions and that MC4R signaling loss leads to vascular diseases, such as vascular vulnerability and abdominal aortic aneurysm (AAA). To understand the molecular mechanism by which myeloid MC4R inhibits atherosclerosis and Ang II-induced AAA in mice, we first conducted a microarray analysis of LysM (+);MC4RTB/TB and MC4RTB/TB mouse primary BM-derived macrophages.

2022-03-21 | GSE198975 | GEO

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