Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing of healthy human airway epithelia with IL-13 treatment time course

ABSTRACT: RNA sequencing of healthy human airway epithelia with IL-13 treatment time course

PROVIDER: PRJNA1005180 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25629300_1.fastq.gz	Fastqsanger.gz
	SRR25629300_2.fastq.gz	Fastqsanger.gz
	SRR25629301_1.fastq.gz	Fastqsanger.gz
	SRR25629301_2.fastq.gz	Fastqsanger.gz
	SRR25629302_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 144

Similar Datasets

RNA sequencing of healthy human airway epithelia with IL-13 treatment time course

Project description:The goal of this study was to examine changes to gene expression induced by IL-13 treatment of air-liquid interface cultures of healthy primary human airway epithelia over time.

2023-08-16 | GSE240741 | GEO

Single cell RNA sequencing of healthy human airway epithelia with IL-13 treatment time course

Project description:The goal of this study was to examine changes in cell composition and gene expression with IL-13 treatment over time within different cell types from air-liquid interface cultures from healthy primary human airway epithelia.

2024-04-12 | GSE229202 | GEO

Single cell RNA sequencing of healthy human airway epithelia with IL-13 treatment time course

Project description:Single cell RNA sequencing of healthy human airway epithelia with IL-13 treatment time course

| PRJNA953399 | ENA

Single cell RNA sequencing of healthy human airway epithelia

Project description:The goal of this study was to compare cell composition and gene expression of different cell types in healthy primary human airway epithelia cultured at the air-liquid interface

2021-10-02 | GSE185048 | GEO

IL-13 decreases suceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo [Bulk RNA-seq]

Project description:Human airway epithelia (HAE) undergo inflammation-induced remodeling in chronic lung diseases such as asthma and chronic bronchitis. The role of type 2 inflammation-induced epithelial remodeling in SARS-CoV-2 infection and the course of COVID-19 is unclear, moreover, there is discrepancy in the literature regarding the potential benefit of treatments that modulate type 2 inflammation. We investigated the role of IL-13-induced inflammation on SARS-CoV-2 binding/entry, replication, and host response in primary HAE cells in vitro and in a model of mouse-adapted SARS-CoV-2 in vivo. IL-13 protected airway epithelial cells from SARS-CoV-2 infection in vitro by decreasing the abundance of ACE2- expressing ciliated cells rather than by neutralization in the airway surface liquid or by interferon-mediated antiviral effects. In contrast, IL-13 worsened the severity of disease in mice in vivo; the effects were mediated by eicosanoid signaling and were abolished in mice deficient in the phospholipase A2 enzyme PLA2G2D. We conclude that IL-13-induced inflammation affects multiple steps of SARS-CoV-2-induced disease pathogenesis. Whereas IL-13-induced inflammation may be protective against initial infection at the airway epithelium, it enhances disease severity once infection progresses in vivo; blockade of IL-13 and/or eicosanoid signaling may be protective against progression to severe lung disease.

2024-06-26 | GSE249304 | GEO

Single cell RNA sequencing of healthy human airway epithelia

Project description:Single cell RNA sequencing of healthy human airway epithelia

| PRJNA767445 | ENA

Time course of measles infection in healthy human airway epithelial cell cultures

Project description:The goal of this study was to examine changes in gene expression over time in healthy human airway epithelia infected with measles virus.

2023-08-04 | GSE229685 | GEO

Gene Expression Effects of IL-13 on Primary Human Airway Epithelial Cells

Project description:Primary culture airway epithelial cells, grown under physiologic air-liquid interface conditions, with, or without IL-13 in order to study the effects of this cytokine on mucous cell metaplasia, an important feature of asthma and COPD. Keywords: IL13, mucus, goblet cell RNA was isolated from primary culture airway epithelial cells grown at air-liquid interface, treated with or without IL-13 for 21 days.

2012-12-04 | E-GEOD-37693 | biostudies-arrayexpress

Expression data from human airway epithelia exposed to IL13

Project description:IL13 exposure results in a distinct gene expression profile in human airway epithelia. We investigated whether this expression profile can be used to identify compounds able to block goblet cell metaplasia We used microarrays to determine transcriptional changes in cultures of primary human airway epithelia grown at the air-liquid interface after exposure to 20 ng/mL recombinant human IL13

2017-11-14 | GSE106812 | GEO

Effect of IL-13 on transcriptome of differentiated human airway mucociliary epithelium

Project description:We used microarrays to detail the global programme of gene expression that occurs in response to treatment of IL-13 on fully-differentiated human airway mucociliary epithelium

2019-01-10 | GSE110799 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data