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Cardiac transcriptome analysis of BBLN-transgenic mice by NGS

ABSTRACT: Cardiac transcriptome analysis of BBLN-transgenic mice by NGS

PROVIDER: PRJNA1006663 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25685590_1.fastq.gz	Fastqsanger.gz
	SRR25685590_2.fastq.gz	Fastqsanger.gz
	SRR25685591_1.fastq.gz	Fastqsanger.gz
	SRR25685591_2.fastq.gz	Fastqsanger.gz
	SRR25685592_1.fastq.gz	Fastqsanger.gz

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Cardiac transcriptome analysis of BBLN-transgenic mice by NGS

Project description:The study applied NGS to determine the cardiac transcriptomes of BBLN-transgenic mice with FVB/N background in comparison to those of non-transgenic FVB/N mice at an age of 8 months. The BBLN (Bublin coiled-coil protein) is the chromosome 9 open reading frame, C9orf16, with largely unknown function. To investigate the cardiac phenotype of increased cardiac BBLN transcript levels we generated BBLN-transgenic (Tg-BBLN) mice. Echocardiography documented that Tg-BBLN mice developed features of heart failure at an age of 8 months. To elucidate pathomechanisms of heart failure induced by BBLN, we performed NGS of the cardiac transcriptomes of eight-month-old, male, BBLN-transgenic mice with cardiac-specific expression of BBLN under control of the myocardium-specific, alpha-MHC promoter. The non-transgenic control group are age-matched, male, nontransgenic FVB/N mice. NGS data of this study document transcriptome changes underlying the heart failure phenotype induced by transgenic BBLN expression.

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Cardiac transcriptome analysis of RKIP-transgenic and GRK2-transgenic mice by NGS

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Cardiac transcriptome analysis of RKIP-transgenic and GRK2-transgenic mice by NGS

Project description:Cardiac transcriptome analysis of RKIP-transgenic and GRK2-transgenic mice by NGS

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Cardiac transcriptome analysis of right and left ventricular heart specimens of BBLN-transgenic mice by NGS

Project description:The study performed NGS to investigate the cardiac transcriptomes of right and left ventricular heart specimens of 3-4-month-old BBLN-transgenic mice with FVB/N background in comparison to those of non-transgenic FVB/N mice. BBLN-transgenic (Tg-BBLN) mice with myocardium-specific BBLN expression were generated to investigate the cardiac phenotype of increased cardiac BBLN transcript levels because the function of BBLN (Bublin coiled-coil protein), which is the chromosome 9 open reading frame(C9orf16), is largely unknown. Tg-BBLN mice with increased cardiac BBLN levels developed features of heart failure with increasing age. Pathomechanisms of heart failure induced by BBLN were investigated by NGS of right and left ventricular heart specimens of male, BBLN-transgenic mice (age: 3-4 months). NGS data reveal transcriptome changes in right and left ventricular heart specimens induced by increased expression of BBLN in the heart.

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Cardiac transcriptome analysis of right and left ventricular heart specimens of BBLN-transgenic mice by NGS

Project description:Cardiac transcriptome analysis of right and left ventricular heart specimens of BBLN-transgenic mice by NGS

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