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Bacterial lipopolysaccharide-induced inflammation promotes iron accumulation in human adipocytes

ABSTRACT: Bacterial lipopolysaccharide-induced inflammation promotes iron accumulation in human adipocytes

PROVIDER: PRJNA1006670 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25687257_1.fastq.gz	Fastqsanger.gz
	SRR25687257_2.fastq.gz	Fastqsanger.gz
	SRR25687258_1.fastq.gz	Fastqsanger.gz
	SRR25687258_2.fastq.gz	Fastqsanger.gz
	SRR25687259_1.fastq.gz	Fastqsanger.gz

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Bacterial lipopolysaccharide-induced inflammation promotes iron accumulation in human adipocytes

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Project description:Iron accumulation in microglia has been observed in AlzheimerÃ¢Â€Â™s disease and other neurodegenerative disorders and is thought to contribute to disease progression through various mechanisms including neuroinflammation. To study the interaction between iron accumulation and inflammation, we treated human induced pluripotent stem cell-derived microglia (iPSC-MG) with an increasing concentration of iron, in combination with inflammatory stimuli such as interferon gamma and amyloid ÃŽÂ², and performed RNA sequencing.

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SGBS iron secretome - To identify differentially expressed proteins in the secretome of differentiated SGBS cells human adipocytes) in response to iron.

Project description:To identify differentially expressed proteins in the secretome of differentiated SGBS cells human adipocytes) in response to iron.

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