Project description:A large body of evidence suggests that the development and maintenance of corpus luteum (CL) in primates requires the action of LH. Earlier, using CET-induced luteolysis model, we demonstrated changes in luteal transcriptome suggesting nuclear actions of LH in the primate CL. To further demonstrate the role of LH in maintenance of primate CL, replacement studies were carried out and it was observed that administration of a single injection of rhLH was sufficient to restore the progesterone to pre-CET treatment levels and prevent the CET-induced luteolysis. To elucidate the molecular mechanisms underlying the rescue of CL function, we used LH-replacement model to study immediate early changes in gene expression at a global level (Affymetrix oligonucleotide microarray) following LH replacement in CET-treated monkeys and to evaluate if the changes in gene expression mediated by LH-withdrawal can be reversed by LH replacement. Results demonstrated up-and down-regulation of various genes following LH replacement and suggested that LH-withdrawal induced changes in gene expression are reversible at least for some genes. Keywords: CL, CET, rhLH

2007-07-06 | GSE8371 | GEO

E-MEXP-1276

Project description:Transcription profiling by array of pancreatic cells from C57BL/6 mice following dibenzazepine treatment

2014-07-03 | E-MEXP-1276 | ExpressionAtlas

E-GEOD-37148

Project description:Transcriptome Profiling following Neuronal and Glial Expression of ALS-linked SOD1 in Drosophila

2015-09-28 | E-GEOD-37148 | ExpressionAtlas

E-GEOD-1721

Project description:Transcription profiling of rat kidney samples following treatment with the corticosteroid methylprednisolone over several time intervals

2015-07-07 | E-GEOD-1721 | ExpressionAtlas

Expression profiling of primate CL following PGF2alpha treatment

Project description:Corpus luteum (CL) is an ephemeral gland whose main function is to secrete progesterone required for the establishment and maintenance of pregnancy. In non-fertile cycles, primate CL has a finite life span of 14-16 days, following which it undergoes regression. Although it has been suggested long time back that PGF2alpha of intra-ovarian or intra-luteal origin acts as a physiological luteolysin in primates, the mechanisms by which PGF2alpha mediates its luteolytic actions are poorly understood. Earlier, we standardized an induced luteolysis model, where 3 injections of PGF2alpha to female bonnet monkeys on day 10 of luteal phase led to luteolysis. To delineate the mechanism of this PGF2alpha-induced luteolysis, we tried to study the global changes in gene expression following PGF2alpha treatment using Affymetrix microarray analysis of PGF2alpha and VEH treated CL and results suggested that PGF2alpha exerts its luteolytic effects by altering gene expression. Keywords: CL, PGF2alpha, VEH, gene expression

2007-06-02 | GSE7971 | GEO

E-GEOD-53552

Project description:Gene expression profiling in psoriatic lesional and non-lesional skin [brodalumab treatment]

2025-01-24 | E-GEOD-53552 | ExpressionAtlas

E-MEXP-1176

Project description:Transcription profiling by array of mouse hepatocytes following treatment with growth factor beta 1 in a time series

2014-07-31 | E-MEXP-1176 | ExpressionAtlas