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Improving blood vessel function in peripheral artery disease: endothelial-derived TRAIL generates stable microvessels in ischemia via TRAIL-R2

ABSTRACT: Improving blood vessel function in peripheral artery disease: endothelial-derived TRAIL generates stable microvessels in ischemia via TRAIL-R2

PROVIDER: PRJNA1012805 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR25904100.fastq.gz	Fastqsanger.gz
	SRR25904101.fastq.gz	Fastqsanger.gz
	SRR25904102.fastq.gz	Fastqsanger.gz
	SRR25904103.fastq.gz	Fastqsanger.gz
	SRR25904104.fastq.gz	Fastqsanger.gz

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Improving blood vessel function in peripheral artery disease: endothelial-derived TRAIL generates stable microvessels in ischemia via TRAIL-R2

Project description:Ischemia reduction in peripheral artery disease (PAD) through angiogenesis requires endothelial cell (EC) and pericyte interactions to form stable microvascular networks, but processes mediating this are disrupted in PAD. Patients with cardiovascular disease have suppressed levels of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). The contribution of endothelial cell (EC)-derived TRAIL to generating stable blood vessel networks and the impact of its receptors in PAD is unknown.We used scRNA-seq to identify molecular determinants that are altered in ischemic tissues of EC-specifc TRAIL KO mice vs littremate control mice, specifically looking at EC-pericyte interactions.

2024-08-19 | GSE242268 | GEO

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Project description:Rat retinal microvessels (RMVs) and brain microvessels (BMVs) were mechanically isolated under ice-cold condition. Retinal and brain tissues (RT, BT) from the same animals were collected for comparisons. Total RNA were individually extracted, amplified and processed on Affymetrix rat 2.0 microarray Chips. We sought to obtain the whole gene expression profile of RMVs, RT, BMVs and BT. Differently expressed genes (DEGs) between RMVs and RT, and between RMVs and BMVs, between RT and BT were analyses. Using these DEGs, we comprehensively analyzed gene expression of the microvessels and highlighted their involvement in critical functional structures in RMVs and BMVs, such as junctional complex, transporters and signaling pathways.

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Defining the Phosphodiesterase Superfamily Members in Rat Brain Microvessels

Project description:A filtration method followed by microarray analyses allows PDE components to be identified in brain microvessels, and confirmed that PDE4D and PDE5A are the primary forms expressed in rat brain microvessels. Adult male F344 rats were sacrificed and blocks of the cerebral cortex and infratentorial areas were dissected. Microvessels were isolated using a filtration method, and total RNA was extracted. Two microarrays using four sample RNAs (microvessels from the cerebral cortex vs. microvessels from the infratentorial block) were included in the present study. Microarrays demonstrated that there were 16 PDE transcripts in the PDE superfamily, exhibiting quantifiable density in the microvessels.

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Gene expression profiling of the retinal microvessels and the brain microvessels

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Project description:To investigate the stroke-induced changes in gene expression in cerebral microvessels, we subjected mice to transient middle cerebral artery occlusion (tMCAO) or sham surgeries. 24h hours later, cerebral microvessels were harvested and RNA was isolated. We then performed gene expression profiling analysis using data obtained from RNA-seq of cerebral microvessels isolated from 8 mice (4 shams and 4 tMCAO)

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