Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Lipids impair NK cell anti-tumor immunity and transcription [ATAC-seq]

ABSTRACT: Lipids impair NK cell anti-tumor immunity and transcription [ATAC-seq]

PROVIDER: PRJNA1013581 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR25933825_1.fastq.gz	Fastqsanger.gz
	SRR25933825_2.fastq.gz	Fastqsanger.gz
	SRR25933826_1.fastq.gz	Fastqsanger.gz
	SRR25933826_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Lipids impair NK cell anti-tumor immunity and transcription

Project description:Lipids impair NK cell anti-tumor immunity and transcription

| PRJNA1013577 | ENA

Lipids impair NK cell anti-tumor immunity and transcription [RNA-seq]

Project description:Lipids impair NK cell anti-tumor immunity and transcription [RNA-seq]

| PRJNA1013582 | ENA

Lipids impair NK cell anti-tumor immunity and transcription [RNA-seq]

Project description:NK cell is an important immune cell, we detected the change of transcription level after OA treatment (0.2mM oleic acid (OA) for 36h. The treatment processed only once.).

2024-09-03 | GSE242490 | GEO

Lipids impair NK cell anti-tumor immunity and transcription [ATAC-seq]

Project description:NK cell is an important immune cell, we detected the change of chromatin accessibility after OA treatment (0.2mM oleic acid (OA) for 36h. The treatment processed only once.)

2024-09-03 | GSE242491 | GEO

TGF-β and CIS inhibition overcomes NK cell suppression to restore anti-tumor immunity

Project description:Antibodies targeting “immune checkpoints” have revolutionized cancer therapy by reactivating tumor-resident cytotoxic lymphocytes, primarily CD8 T cells. Interest in targeting analogous pathways in other cytotoxic lymphocytes is growing. Natural killer (NK) cells are key to cancer immunosurveillance by eradicating metastases and driving solid tumor inflammation. NK cell anti-tumor function is dependent on the cytokine interleukin (IL)-15. Ablation of the IL-15 signaling inhibitor CIS (Cish) enhances NK cell anti-tumor immunity by increasing NK cell metabolism and persistence within the tumor microenvironment (TME). The TME has also been shown to impair NK cell fitness via the production of immunosuppressive TGF-b, a suppression which occurs even in the presence of high IL-15 signaling. Here, we identified an unexpected interaction between CIS and the TGF-b signaling pathway in NK cells. Independently, Cish- and Tgfbr2- deficient NK cells are both hyper-responsive to IL-15 and hypo-responsive to TGF-b, with dramatically enhanced anti-tumor immunity. Remarkably, when both these immunosuppressive genes are simultaneously deleted in NK cells, mice are largely resistant to tumor development, suggesting that combining suppression of these two pathways might represent a novel therapeutic strategy to enhance innate anti-cancer immunity.

2022-04-11 | GSE200134 | GEO

The RNA m6A reader YTHDF2 controls NK cell anti-tumor and anti-viral immunity

Project description:N6-methyladenosine (m6A) is the most prevalent post-transcriptional modification on RNA. NK cells are the predominant innate lymphoid cells that mediate anti-viral and anti-tumor immunity. However, whether and how m6A modifications affect NK cell immunity remains unknown. Here, we discover that YTHDF2, a well-known m6A reader, is upregulated in NK cells upon activation by cytokines, tumors, and cytomegalovirus infection. Ythdf2 deficiency in NK cells impairs NK cell anti-tumor and anti-viral activity in vivo. YTHDF2 maintains NK cell homeostasis and terminal maturation, correlating with modulating NK cell trafficking and regulating Eomes, respectively. YTHDF2 promotes NK cell effector function and is required for IL-15-mediated NK cell survival and proliferation by forming a STAT5-YTHDF2 positive feedback loop. Transcriptome-wide screening identifies Tardbp to be involved in cell proliferation or survival as a YTHDF2-binding target in NK cells. Collectively, we elucidate the biological roles of m6A modifications in NK cells and highlight a new direction to harness NK cell anti-tumor immunity.

2021-05-08 | GSE174027 | GEO

Lipids impair NK cell anti-tumor immunity and transcription

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-09-03 | GSE242492 | GEO

FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity

Project description:FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity

| PRJNA1040880 | ENA

Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity

Project description:Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity

| PRJNA728903 | ENA

The RNA m6A reader YTHDF2 controls NK cell anti-tumor and anti-viral immunity

Project description:The RNA m6A reader YTHDF2 controls NK cell anti-tumor and anti-viral immunity