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Plantain flour - a beneficial material for the organ and transcriptional profile of kidney of diabetic rats

ABSTRACT: Plantain flour - a beneficial material for the organ and transcriptional profile of kidney of diabetic rats

PROVIDER: PRJNA1015209 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26034729_1.fastq.gz	Fastqsanger.gz
	SRR26034729_2.fastq.gz	Fastqsanger.gz
	SRR26034730_1.fastq.gz	Fastqsanger.gz
	SRR26034730_2.fastq.gz	Fastqsanger.gz
	SRR26034731_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Plantain flour - a beneficial material for the organ and transcriptional profile of kidney of diabetic rats

Project description:This study investigated the ameliorative effects of plantain flour on the organs of diabetic rats, and explored the mechanism from the perspective of kidney transcription. Diabetes was induced in rats by streptozotocin (STZ) and a high-sugar and high-fat diet. The alleviation effects and molecular mechanism of diabetes by plantain flour at different doses (1g/kg·Bw, 2g/kg·Bw, and 4g /kg·Bw) were evaluated based on the analysis of biochemical indicators, histological observations, homeostasis model, and kidney transcriptome. The findings demonstrated that the intervention of plantain flour can reduce the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and urea (UREA). The pathological study revealed that plantain flour can alleviate the pathological symptoms of fat accumulation in liver and kidney tissue. According to the homeostasis model, plantain flour was able to reduce insulin resistance in diabetic rats. Transcriptome analysis showed that plantain flour improved dyslipidemia by up-regulating Acsl1, down-regulating Fabp4 and Plin1, and reduced kidney injury by up-regulating Slco1a6, Hsd17b2, Cyp2c24, and Cyp2c11 genes. These results suggested that plantain flour could recover the organ damage caused by diabetes and has the potential to be developed into healthy food.

2023-09-30 | GSE242876 | GEO

Effects of plantain on transcriptional profile of liver in obese rats

Project description:We explored the mechanisms underlying the anti-obesity effect of plantain. Plantain flour was used to feed obese rats fed a high-fat diet. Six groups were set, viz., the normal control (NC), obese control (OC), low-dose (LD), middle-dose (MD), high-dose (HD), and positive control (PC). The differentially expressed genes in the liver, as well as the lipid and glucose metabolic pathways were investigated. Transcriptome analyses showed that the expression of the PPARα, CPT1A, AMPK, and PGC1α genes was upregulated in the plantain intervention groups. Conclusion: Some key genes in fatty acid and sugar metabolic pathways were regulated by the plantain diet, which probably led to the observed fat and weight loss effects.

2022-09-15 | GSE213188 | GEO

Aquifer material

Project description:Aquifer material Metagenome

| PRJNA720508 | ENA

Genome-wide survey of transcriptional differences between males and females of Tribolium castaneum, the red flour beetle

Project description:Genome-wide survey of transcriptional differences between males and females of Tribolium castaneum, the red flour beetle

2010-05-27 | GSE18087 | GEO

multifunction material

Project description:multifunction material Raw sequence reads

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Cultural heritage material

Project description:Cultural heritage material Metagenome

| PRJNA698004 | ENA

novel PRB material

Project description:novel PRB material Raw sequence reads

| PRJNA624830 | ENA

alcoholic fermentative material

Project description:alcoholic fermentative material high-throughput sequencing

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Coptotermes spp. nest material

Project description:Coptotermes spp. nest material Metagenome

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Genome-wide survey of transcriptional differences between males and females of Tribolium castaneum, the red flour beetle

Project description:Genome-wide survey of transcriptional differences between males and females of Tribolium castaneum, the red flour beetle Four biological replicates for male and female beetles with 20 individuals per replicate. Two technical replicates, one replicate per sex. 16,434 genes/expressed non-coding regions represented twice on each array. Three 60 mer probes for most exons/expressed non-coding regions. 167,538 unique genomic probes replicated twice per array.

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