Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA101563 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia. We evaluated whether healthy aging was associated with a transcriptional profile reflecting mitochondrial impairment and whether resistance exercise could reverse this signature to that approximating a younger physiological age. Skeletal muscle biopsies from healthy older (N = 25) and younger (N = 26) adult men and women were compared using gene expression profiling, and a subset of these were related to measurements of muscle strength. 14 of the older adults had muscle samples taken before and after a six-month resistance exercise-training program. Before exercise training, older adults were 59% weaker than younger, but after six months of training in older adults, strength improved significantly (P<0.001) such that they were only 38% lower than young adults. As a consequence of age, we found 596 genes differentially expressed using a false discovery rate cut-off of 5%. Prior to the exercise training, the transcriptome profile showed a dramatic enrichment of genes associated with mitochondrial function with age. However, following exercise training the transcriptional signature of aging was markedly reversed back to that of younger levels for most genes that were affected by both age and exercise. We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training. Keywords: resistance exercise, muscle, aging
2007-07-16 | GSE8479 | GEO
Project description:Human skeletal muscle transcriptional response to exercise
| PRJNA140403 | ENA
Project description:Human skeletal muscle transcriptome responses to differentiated exercise
| PRJNA254471 | ENA
Project description:Time and Exercise effects on Human Skeletal Muscle
| PRJNA90403 | ENA
Project description:Transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training
| PRJNA193700 | ENA
Project description:DERBY BBSRC RET Study: Impact of resistance exercise on human skeletal muscle gene expression
| PRJNA208236 | ENA
Project description:Aging and MicroRNA Expression in Human Skeletal Muscle
| PRJNA131783 | ENA
Project description:Exercise Mitigates Skeletal Muscle Epigenetic Aging
| PRJNA732356 | ENA
Project description:cDNA microarray analysis of human skeletal muscle after eccentric exercise
| PRJNA104621 | ENA
Project description:cDNA microarray analysis of human skeletal muscle after endurance exercise
| PRJNA104619 | ENA