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T cell dysfunction in ARDS based on miRNA and mRNA integration analysis (RNA-Seq)

ABSTRACT: T cell dysfunction in ARDS based on miRNA and mRNA integration analysis (RNA-Seq)

PROVIDER: PRJNA1016318 | ENA |

REPOSITORIES: ENA

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T cell dysfunction in ARDS based on miRNA and mRNA integration analysis (miRNA-Seq)

Project description:Acute respiratory distress syndrome (ARDS) is a respiratory failure in critically ill patients, and the molecular mechanisms underlying its pathogenesis and severity are poorly understood. We evaluated mRNA and miRNA in patients with ARDS and elucidated the pathogenesis of ARDS, following mRNA and miRNA integration analysis. Thirty-four ARDS patients were compared with 15 healthy donors. 1233 mRNAs and 6 miRNAs were upregulated and 1580 mRNAs and 13 miRNAs were downregulated in ARDS patients compared healthy donors. In both mRNA and miRNA-targeted mRNA, the canonical pathway analysis showed that PD-1 and PD-L1 cancer immunotherapy pathway was most activated and Th2 pathway was most suppressed. miR-149-3p and several miRNAs were identified as upstream regulators. Integrated analysis of mRNAs and miRNAs showed that T cells were dysfunctional in ARDS patients.

2024-03-15 | GSE243067 | GEO

T cell dysfunction in ARDS based on miRNA and mRNA integration analysis (RNA-Seq)

2024-03-15 | GSE243066 | GEO

T cell dysfunction in ARDS based on miRNA and mRNA integration analysis

Project description:T cell dysfunction in ARDS based on miRNA and mRNA integration analysis

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T cell dysfunction in ARDS based on miRNA and mRNA integration analysis (miRNA-Seq)

Project description:T cell dysfunction in ARDS based on miRNA and mRNA integration analysis (miRNA-Seq)

| PRJNA1016320 | ENA

T cell dysfunction in elderly ARDS patients based on miRNA and mRNA integration analysis.

Project description:BackgroundAcute respiratory distress syndrome (ARDS) is respiratory failure that commonly occurs in critically ill patients, and the molecular mechanisms underlying its pathogenesis and severity are poorly understood. We evaluated mRNA and miRNA in patients with ARDS and elucidated the pathogenesis of ARDS after performing mRNA and miRNA integration analysis.MethodsIn this single-center, prospective, observational clinical study of patients with ARDS, peripheral blood of each patient was collected within 24 hours of admission. Sequencing of mRNA and miRNA was performed using whole blood from the ARDS patients and healthy donors.ResultsThirty-four ARDS patients were compared with 15 healthy donors. Compared with the healthy donors, 1233 mRNAs and 6 miRNAs were upregulated and 1580 mRNAs and 13 miRNAs were downregulated in the ARDS patients. For both mRNA and miRNA-targeted mRNA, canonical pathway analysis showed that programmed death-1 (PD-1) and programmed cell death ligand 1 (PD-L1) cancer immunotherapy pathway was most activated and the Th2 pathway was most suppressed. For mRNA, the Th1 pathway was most suppressed. miR-149-3p and several miRNAs were identified as upstream regulators.ConclusionmiRNAs regulated the PD-1 and PD-L1 cancer immunotherapy pathway and Th2 pathway through miRNA interference action of mRNA. Integrated analysis of mRNAs and miRNAs showed that T cells were dysfunctional in ARDS patients.

| S-EPMC10987699 | biostudies-literature

miRNA expression profiles in rat Acute Respiratory Distress Syndrome (ARDS)

Project description:Rat model of ARDS was induced by saline lavage and mechanical ventilation. miRNA from rat lungs were used for dual color DNA microarray hybridization with 3DNA 50 kit version 2. Two-condition experiment, CON vs. ARDS lung tissues. replicates: 6 control, 6 ARDS. One replicate per array.

2014-05-07 | E-GEOD-57223 | biostudies-arrayexpress

T cell dysfunction in ARDS based on miRNA and mRNA integration analysis

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-03-15 | GSE243068 | GEO

miRNA expression profiles in rat Acute Respiratory Distress Syndrome (ARDS)

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Project description:The roles of mRNA and microRNA (miRNA) are widely known in many diseases including acute ischemic stroke. About 60 % of all human messenger RNAs (mRNAs) are regulated by microRNAs. Integration analysis using mRNA and miRNA are important to elucidate pathogenesis. But the contribution of mRNA and miRNA, especially miRNA targeted mRNA, related with severity of acute ischemic stroke is not remain understood. To clarify the pathway related with the severity of acute ischemic stroke, we examined mRNA and miRNA integration analysis targeted for acute ischemic stroke.

2023-08-11 | GSE202518 | GEO

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