Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Diffrential expression of urinary bladder cells microRNAs ( miRs) in cyclophosphamide induced cystitis

ABSTRACT: Diffrential expression of urinary bladder cells microRNAs ( miRs) in cyclophosphamide induced cystitis

PROVIDER: PRJNA1017460 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Diffrential expression of urinary bladder cells microRNAs ( miRs) in cyclophosphamide induced cystitis

Project description:During cyclophosphamide (CYP) induced ctstitis progression differential expression of microRNAs (miRs) play a role in urinary bladder inflammation and detrusor function. We identified eight UBs miRs that are known to be involved in various other bladder pathologies which exhibited altered expression in CYP mice and e predicted to have a role in inflammation and smooth muscle function (miR-34c-5p, -34b-3p, -212-3p, -449a-5p, -21a-3p, -376b-3p, -376b-5p and -409-5p).

2023-09-18 | GSE243239 | GEO

MicroRNAs dysregulation in experimental interstitial cystitis

Project description:We compared the chnages in urinary bladder and iliac lymph nodes microRNAs in the control and experimental autoimmune cystitis in mice. A set of urinary bladder microRNAs (miRNAs) shows profound upregulation or downregulation in the expression profiles of the experimental IC as compared to control.

2021-06-12 | GSE177066 | GEO

Expression data from mouse whole bladders of cyclophosphamide-induced cystitis

2014-03-18 | GSE55986 | GEO

Expression data from mouse whole bladders of cyclophosphamide-induced cystitis

Project description:To analyze the gene expression of non-bacterial bladdder inflammation, mouse cyclophosphamide(CYP)-induced model of cystitis was adapted. Forty-eight hour after CYP or vehicle treatment, total RNA was extracted from CYP-treated group (CYP150) and control group (CYP0). We used microarrays to detail the gene expression underlying bladder inflammation. Five-week-old female Balbc/A mice were injected intraperitoneally with 150mg/kg body weight of CYP diluted in 15ml/kg body weight of saline. Mice injected with saline alone served as controls. Treated mice were killed 48 hours after administaration and the whole bladders harvested. Total RNA was extracted and microarray analysis was performed.

2014-03-18 | E-GEOD-55986 | biostudies-arrayexpress

Gene expression evaluation of urinary bladder in mouse model of long-term ketamine injection

Project description:The aim of this cDNA array study is to search for advanced markers related to the pathogenesis of ketamine-induced cystitis. The result revealed a number of gene expressions involved in chronic wound healing response and collagen accumulation, which were closely related to fibrosis progression in the connective tissue of mice urinary bladder.

2016-05-01 | GSE68539 | GEO

Correlation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome

2014-05-13 | GSE57560 | GEO

Urinary bladder in constant darkness: time course

Project description:Analysis of urinary bladder in wild-type C57BL/6 females sacrificed every 4 hours at six time points under constant darkness after acclimation for 2 weeks under 12-hour light and 12-hour dark conditions. Results provide insight into circadian gene expression patterns in normal urinary bladder. Analysis of urinary bladder in wild-type C57BL/6 females sacrificed every 4 hours at six time points (n=2 for each time (CT 0, 4, 8, 12 and 20)) under constant darkness after acclimation for 2 weeks under 12-hour light and 12-hour dark conditions.

2012-04-30 | E-GEOD-35795 | biostudies-arrayexpress

Chronic cystitis microarray comparing C3H/HeN and C57BL/6 bladder gene expression

Project description:Mice were infected with the cystitis isolate UTI89 transurethrally and sacrificed 28 days post infection. Total bladder RNA was harvested from mock, resolved or chronic bladder and analyzed using the mouse gene 1.0 st chips.

2014-12-06 | E-MTAB-2930 | biostudies-arrayexpress

Correlation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome

Project description:Interstitial cystitis (IC) and bladder pain syndrome are terms used to describe a heterogenous chronic pelvic and bladder pain disorder of unknown etiology. The goal of this pilot study was to determine if gene expression profiling of bladder biopsy tissue from patients experiencing symptoms could be used to separate the patients based on some clinical parameter. Gene expression profiles in bladder biopsy tissue from patients with: (1) low bladder capacity (defined here as <400 ml upon hydordistension), (2) normal capacity (M-bM-^IM-%400 ml), and (3) controls were compared. Gene expression profiles from low bladder capacity tissues differed significantly from normal capacity and control tissue, suggesting gene expression profiling may be a useful tool for better understanding IC disease pathophysiology.

2014-05-13 | E-GEOD-57560 | biostudies-arrayexpress

Urinary bladder in constant darkness: time course

2012-05-01 | GSE35795 | GEO