Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11dTAG_sPOINT-seq)

ABSTRACT: Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11dTAG_sPOINT-seq)

PROVIDER: PRJNA1017502 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26062645_1.fastq.gz	Fastqsanger.gz
	SRR26062645_2.fastq.gz	Fastqsanger.gz
	SRR26062646_1.fastq.gz	Fastqsanger.gz
	SRR26062646_2.fastq.gz	Fastqsanger.gz
	SRR26062647_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11-dTAG_ChIP-seq)

Project description:RNA polymerase II (RNAPII) transcription initiates bidirectionally at many human protein-coding genes. Sense transcription usually dominates and leads to messenger RNA production, whereas antisense transcription rapidly terminates. The basis for this directionality is not fully understood. Here, we show that sense transcriptional initiation is more efficient and focused than in the antisense direction. After transcription begins, directionality is maintained by the opposing functions of Integrator (INTS11) and cyclin-dependent kinase 9 (CDK9). INTS11 terminates antisense transcription, whereas sense transcription is protected from this attenuation by CDK9. However, INTS11 terminates transcription in both directions upon CDK9 inhibition, and the engineered recruitment of CDK9 abrogates attenuation by INTS11. Therefore, transcriptional initiation and the asymmetric activities of CDK9 and INTS11 explain the attenuation of antisense transcription, the more extensive nature of sense transcription, and promoter directionality.

2024-03-19 | GSE243259 | GEO

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (RBBP6_POINT-Seq)

2024-03-19 | GSE243265 | GEO

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11dTAG_POINT-seq)

2024-03-19 | GSE243262 | GEO

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (TS11dTAG_NVP2_POINT-seq)

2024-03-19 | GSE243260 | GEO

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11dTAG_sPOINT-seq)

2024-03-19 | GSE243264 | GEO

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11-dTAG_ChIP-seq)

Project description:Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11-dTAG_ChIP-seq)

| PRJNA1017496 | ENA

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

Project description:Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9

| PRJNA1017492 | ENA

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11dTAG_POINT-seq)

Project description:Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (INTS11dTAG_POINT-seq)

| PRJNA1017501 | ENA

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (TS11dTAG_NVP2_POINT-seq)

Project description:Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (TS11dTAG_NVP2_POINT-seq)

| PRJNA1017499 | ENA

Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (RBBP6_POINT-Seq)

Project description:Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9 (RBBP6_POINT-Seq)

| PRJNA1017504 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data