Ontology highlight
ABSTRACT:
PROVIDER: PRJNA1017651 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:RNAseq analysis of caecal tissue from 14 C. jejuni-susceptible and 14 C. jejuni-resistant birds from a single population of infected chickens was conducted in order to identify gene expression associated with resistance to colonization. Significantly higher expression of genes involved in the innate immune response, cytokine signaling, B cell and T cell activation and immunoglobulin production, as well as the renin-angiotensin system was observed in resistant birds. A population of 255 Barred Rock chickens were orally inoculated with C. jejuni and their caecal colonization levels estimated 48 hours post-inoculation. Caecal samples from 14 birds with no colonization and the 14 birds with the highest colonization were selected for mRNA sequencing.
2013-02-15 | E-GEOD-44341 | biostudies-arrayexpress
Project description:Land cover change has long been recognized that marked effect the amount of soil organic carbon. However, little is known about microbial-mediated effect processes and mechanism on soil organic carbon. In this study, the soil samples in a degenerated succession from alpine meadow to alpine steppe meadow in Qinghai-Tibetan Plateau degenerated, were analyzed by using GeoChip functional gene arrays.
2017-01-05 | GSE93158 | GEO
Project description:Innate immunity is expected to play a primary role in conferring resistance to novel infectious diseases, but few studies have attempted to examine its role in the evolution of resistance to emerging pathogens in wild vertebrate populations. Here we used experimental infections and cDNA microarrays to examine whether changes in the innate and/or acquired immune responses likely accompanied the emergence of resistance in house finches (Carpodacus mexicanus) in the eastern United States subject to a recent outbreak of conjunctivitis-causing bacterium (Mycoplasma gallisepticum- MG). Three days following experimental infection with MG, we observed differences in the splenic transcriptional responses between House Finches from eastern U.S. populations, with a 12-year history of MG exposure, versus western U.S. populations, with no history of exposure to MG. In particular, western birds down-regulated gene expression, while eastern finches showed no expression change relative to controls. Studies involving poultry have shown that MG can manipulate host immunity, and our observations suggest that pathogen manipulation occurred only in finches from the western populations, outside the range of MG. Fourteen days after infection, eastern finches, but not western finches, up-regulated genes associated with acquired immunity (cell-mediated immunity) relative to controls. These observations suggest population differences in the temporal course of the response to infection with MG, and imply that innate immune processes were targets of selection in response to MG in the eastern U.S. population. Birds were randomly selected to be kept either as controls or infected via ocular inoculation with 20 μl of culture containing 1 x 104 to 1 x 106 color changing units/ml of an early 2007 Auburn MG isolate. All infected birds were inoculated with precisely the same volume of the same culture. Control birds were sham infected using sterile SP4 medium (Whitcomb 1983). Infected birds were euthanized three days (N=6 from Arizona and N=11 from Alabama) and 14 days (N=11 from Arizona and N=12 from Alabama) after treatment. Control birds were euthanized 14 days after sham-inoculation; Control (N=11 birds from Arizona and 9 from Alabama) and infected birds were maintained under identical conditions, but in separate rooms of an aviary. Infected birds were euthanized three days (N=6 from Arizona and N=11 from Alabama) and 14 days (N=11 from Arizona and N=12 from Alabama) after treatment. Control birds were euthanized 14 days after sham-inoculation. We used a common reference design (Yang & Speed 2002), in which we pooled 2 to 6 spleens from birds from the same population in the same treatment to generate enough mRNA for microarray hybridizations and hybridized two pools for each treatment from each population.
2012-02-24 | E-GEOD-35931 | biostudies-arrayexpress
Project description:RNAseq analysis of caecal tissue from 14 C. jejuni-susceptible and 14 C. jejuni-resistant birds from a single population of infected chickens was conducted in order to identify gene expression associated with resistance to colonization. Significantly higher expression of genes involved in the innate immune response, cytokine signaling, B cell and T cell activation and immunoglobulin production, as well as the renin-angiotensin system was observed in resistant birds.
2013-02-15 | GSE44341 | GEO
Project description:The evolution of advanced cognition in vertebrates is associated with the expansion of specialized areas in the forebrain (the six-layered neocortex in mammals and the dorsal ventricular ridge in birds and reptiles). Both areas exhibit complementary higher order brain functions, but it remains debated whether they developed convergently, or descended from a brain region already present in the last common ancestor of amniotes. To reconcile these views, we investigated the development, molecular identity, and connectivity of telencephalic neuron types in the Spanish newt, Pleurodeles waltl. These reveal that major neuron classes are conserved in tetrapods. Additionally, a glutamatergic neuron type in the ventral pallium displays key characteristics similar to the reptilian dorsal ventricular ridge (aDVR) and the mammalian piriform cortex (PC), suggesting that brain areas for advanced cognition evolved independently in mammals and reptiles and birds.
2022-09-02 | GSE198365 | GEO
Project description:The evolution of advanced cognition in vertebrates is associated with the expansion of specialized areas in the forebrain (the six-layered neocortex in mammals and the dorsal ventricular ridge in birds and reptiles). Both areas exhibit complementary higher order brain functions, but it remains debated whether they developed convergently, or descended from a brain region already present in the last common ancestor of amniotes. To reconcile these views, we investigated the development, molecular identity, and connectivity of telencephalic neuron types in the Spanish newt, Pleurodeles waltl. These reveal that major neuron classes are conserved in tetrapods. Additionally, a glutamatergic neuron type in the ventral pallium displays key characteristics similar to the reptilian dorsal ventricular ridge (aDVR) and the mammalian piriform cortex (PC), suggesting that brain areas for advanced cognition evolved independently in mammals and reptiles and birds.
2022-09-02 | GSE206163 | GEO
Project description:The evolution of advanced cognition in vertebrates is associated with the expansion of specialized areas in the forebrain (the six-layered neocortex in mammals and the dorsal ventricular ridge in birds and reptiles). Both areas exhibit complementary higher order brain functions, but it remains debated whether they developed convergently, or descended from a brain region already present in the last common ancestor of amniotes. To reconcile these views, we investigated the development, molecular identity, and connectivity of telencephalic neuron types in the Spanish newt, Pleurodeles waltl. These reveal that major neuron classes are conserved in tetrapods. Additionally, a glutamatergic neuron type in the ventral pallium displays key characteristics similar to the reptilian dorsal ventricular ridge (aDVR) and the mammalian piriform cortex (PC), suggesting that brain areas for advanced cognition evolved independently in mammals and reptiles and birds.
2022-09-02 | GSE198366 | GEO
Project description:The evolution of advanced cognition in vertebrates is associated with the expansion of specialized areas in the forebrain (the six-layered neocortex in mammals and the dorsal ventricular ridge in birds and reptiles). Both areas exhibit complementary higher order brain functions, but it remains debated whether they developed convergently, or descended from a brain region already present in the last common ancestor of amniotes. To reconcile these views, we investigated the development, molecular identity, and connectivity of telencephalic neuron types in the Spanish newt, Pleurodeles waltl. These reveal that major neuron classes are conserved in tetrapods. Additionally, a glutamatergic neuron type in the ventral pallium displays key characteristics similar to the reptilian dorsal ventricular ridge (aDVR) and the mammalian piriform cortex (PC), suggesting that brain areas for advanced cognition evolved independently in mammals and reptiles and birds.
2022-09-02 | GSE198364 | GEO
Project description:The evolution of advanced cognition in vertebrates is associated with the expansion of specialized areas in the forebrain (the six-layered neocortex in mammals and the dorsal ventricular ridge in birds and reptiles). Both areas exhibit complementary higher order brain functions, but it remains debated whether they developed convergently, or descended from a brain region already present in the last common ancestor of amniotes. To reconcile these views, we investigated the development, molecular identity, and connectivity of telencephalic neuron types in the Spanish newt, Pleurodeles waltl. These reveal that major neuron classes are conserved in tetrapods. Additionally, a glutamatergic neuron type in the ventral pallium displays key characteristics similar to the reptilian dorsal ventricular ridge (aDVR) and the mammalian piriform cortex (PC), suggesting that brain areas for advanced cognition evolved independently in mammals and reptiles and birds.
2022-09-02 | GSE198363 | GEO