Project description:Gene expression profiling of immortalized human mesenchymal stem cells with hTERT/E6/E7 transfected MSCs. hTERT may change gene expression in MSCs. Goal was to determine the gene expressions of immortalized MSCs.
Project description:Transcriptional profiling of human mesenchymal stem cells comparing normoxic MSCs cells with hypoxic MSCs cells. Hypoxia may inhibit senescence of MSCs during expansion. Goal was to determine the effects of hypoxia on global MSCs gene expression.
Project description:Genomic profiling of a panel of 74 adult male germ cell tumors of various histologies from primary and metastatic sites using high resolution BAC array CGH. See Pubmed ID # 17943972. Completed Study: Statistical analyses were performed to identify regions that were frequently altered in all tumors, as well as in specific histologic subsets and from different tumor sites (i.e., primary gonadal, primary extra-gonadal, and metastatic). Target genes of altered regions were also identified using corresponding tumor expression data (see GEO GSE3218 for expression data). Ongoing: 1) Analysis of high level amplifications and multiple copy number gains and losses and underlying target genes. 2) Regional alterations associated with patient outcome Keywords: tumor profiling
Project description:Gene methylation profiling of immortalized human mesenchymal stem cells comparing HPV E6/E7-transfected MSCs cells with human telomerase reverse transcriptase (hTERT)- and HPV E6/E7-transfected MSCs. hTERT may increase gene methylation in MSCs. Goal was to determine the effects of different transfected genes on global gene methylation in MSCs.