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Aberrant DNA Methylation in Dimethylarsinic Acid-induced Rat Bladder Carcinogenesis

ABSTRACT: Aberrant DNA Methylation in Dimethylarsinic Acid-induced Rat Bladder Carcinogenesis

PROVIDER: PRJNA1017900 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26074023.fastq.gz	Fastqsanger.gz
	SRR26074024.fastq.gz	Fastqsanger.gz
	SRR26074025.fastq.gz	Fastqsanger.gz
	SRR26074026.fastq.gz	Fastqsanger.gz
	SRR26074027.fastq.gz	Fastqsanger.gz

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Aberrant DNA Methylation in Dimethylarsinic Acid-induced Rat Bladder Carcinogenesis

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DNA Methylation Aberrations in Dimethylarsinic Acid-Induced Bladder Carcinogenesis.

Project description:Arsenic is a known human urinary bladder carcinogen. While arsenic is known to cause aberrant DNA methylation, the mechanism of arsenic-triggered bladder carcinogenesis is not fully understood. The goal of this study was to identify aberrant DNA methylation in rat bladder urothelial carcinoma (UC) induced by dimethylarsinic acid (DMAV), a major organic metabolite of arsenic. We performed genome-wide DNA methylation and microarray gene expression analyses of DMAV-induced rat UCs and the urothelium of rats treated for 4 weeks with DMAV. We identified 40 genes that were both hypermethylated and downregulated in DMAV-induced rat UCs. Notably, four genes (CPXM1, OPCML, TBX20, and KCND3) also showed reduced expression in the bladder urothelium after 4 weeks of exposure to DMAV. We also found that CPXM1 is aberrantly methylated and downregulated in human bladder cancers and human bladder cancer cells. Genes with aberrant DNA methylation and downregulated expression in DMAV-exposed bladder urothelium and in DMAV-induced UCs in rats, suggest that these alterations occurred in the early stages of arsenic-induced bladder carcinogenesis. Further study to evaluate the functions of these genes will advance our understanding of the role of aberrant DNA methylation in arsenic bladder carcinogenesis, and will also facilitate the identification of new therapeutic targets for arsenic-related bladder cancers.

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Urinary bladder in F344 rats: Control vs dimethylarsinic acid-induced tumors

Project description:Urinary bladder in F344 rats: Control vs dimethylarsinic acid-induced tumors

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Lung in neonatal mice: Control vs transplacental treated with dimethylarsinic acid (DMA)

Project description:The gene expression profling between Control and transplacental treated with 200 ppm dimethylarsinic acid (DMA) for 10 days in lung of neonatal male mice.

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Lung in neonatal mice: Control vs. transplacental treated with dimethylarsinic acid (DMA)

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2024-06-19 | GSE235455 | GEO

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