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Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD [ATAC-seq]

ABSTRACT: Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD [ATAC-seq]

PROVIDER: PRJNA1018427 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26089367_1.fastq.gz	Fastqsanger.gz
	SRR26089367_2.fastq.gz	Fastqsanger.gz
	SRR26089368_1.fastq.gz	Fastqsanger.gz
	SRR26089368_2.fastq.gz	Fastqsanger.gz
	SRR26089369_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD [RNA-seq]

Project description:The nucleosome remodeling and deacetylase (NuRD) complex is essential for gene expression and cell fate determination, and missense mutations of NuRD caused neurodevelopmental diseases. However, the molecular pathogenesisof clinic NuRD variants is unknown. Here, we introduced a clinic CHD3(L915F) variant into C. elegans homolog LET-418, impairing germline and vulva development and ultimately causing animal sterility. Our ATAC-seq and RNA-seq analyses revealed that this variant generated an abnormal open chromatin structure and disrupted the expression of developmental genes. Through genetic suppressor screens, we uncovered that intragenic mutations, likely renovating NuRD activity, restored animal viability. We also found that intergenic mutations in nucleosome remodeling factor NURF that counteracts NuRD rescued abnormal chromatin structure, gene expression, and animal sterility. We propose that two antagonistic chromatin-remodeling factors coordinate to establish the proper chromatin status and transcriptome and that inhibiting NURF may provide insights for treatment of NuRD mutation-related diseases.

2023-09-21 | GSE243398 | GEO

Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD [ATAC-seq]

2023-09-21 | GSE243397 | GEO

Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD

Project description:Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD

| PRJNA1018419 | ENA

Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD [RNA-seq]

Project description:Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD [RNA-seq]

| PRJNA1018428 | ENA

Inhibition of the chromatin remodeling factor NURF rescued sterility by a clinic variant of NuRD.

Project description:The nucleosome remodeling and deacetylase (NuRD) complex is essential for gene expression and cell fate determination, and missense mutations of NuRD caused neurodevelopmental diseases. However, the molecular pathogenesis of clinic NuRD variants is unknown. Here, we introduced a clinic CHD3 (L915F) variant into Caenorhabditis elegans homologue LET-418, impairing germline and vulva development and ultimately causing animal sterility. Our ATAC-seq and RNA-seq analyses revealed that this variant generated an abnormal open chromatin structure and disrupted the expression of developmental genes. Through genetic suppressor screens, we uncovered that intragenic mutations, likely renovating NuRD activity, restored animal viability. We also found that intergenic mutations in nucleosome remodeling factor NURF that counteracts NuRD rescued abnormal chromatin structure, gene expression, and animal sterility. We propose that two antagonistic chromatin-remodeling factors coordinate to establish the proper chromatin status and transcriptome and that inhibiting NURF may provide insights for treatment of NuRD mutation-related diseases.

| S-EPMC10881175 | biostudies-literature

Inhibition of the Chromatin Remodeling Factor NURF Rescued Sterility by a Clinic Variant of NuRD

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-09-21 | GSE243399 | GEO

clinic collection strains

Project description:clinic collection strains Raw sequence reads

| PRJNA1054306 | ENA

Lactiplantibacillus plantarum strain:Vaginal clinic isolate | isolate:Vaginal clinic isolate

Project description:Lactiplantibacillus plantarum strain:Vaginal clinic isolate | isolate:Vaginal clinic isolate Genome sequencing

| PRJNA886766 | ENA

Increased antigenicity of NURF-depleted tumors enhances CD8 T cell-mediated antitumor immunity

Project description:Depleting the NURF chromatin remodeling complex results in enhanced antitumor immunity using mouse tumor models syngenic to two strain backgrounds. Selective depletion of immune cells from tumor-bearing mice discovers that both CD8+ and CD4+ cells are necessary for enhanced antitumor immunity to NURF-depleted cells. Our results suggest that NURF-depleted cells have significant differences in antigenicity compared to control cells.

2016-04-29 | GSE71864 | GEO

Nascent transcription during NuRD complex induction

Project description:Molecular functions of the Nucleosome Remodeling and Deacetylation (NuRD) complex in the control of gene expression were investigated using an inducible system to direct its assembly in embryonic stem cells. This dataset profiles nascent RNA transcription in response to NuRD induction.

2018-05-31 | E-MTAB-6805 | biostudies-arrayexpress

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