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Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgG)

ABSTRACT: Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgG)

PROVIDER: PRJNA1019350 | ENA |

REPOSITORIES: ENA

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Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgG)

Project description:Increasing evidence supports a role ofthat antibodies in thecan defense protect against active tuberculosis (TB) but knowledge of potentially protective antigens, especially at in the mucosal airways level, is limited. The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses that were associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) compared to uncontrolled infection (TB) in nonhuman primates. We investigated airway and systemic IgG, IgA, and IgM responses in paired bronchoalveolar lavage and plasma samples prior to and two- and 5-6-months post Mtb infection using an antigen-unbiased approach with Mtb glycan and proteome-wide microarrays

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Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgG)

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Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgG)

Project description:Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgG)

| PRJNA1019352 | ENA

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgA)

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Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgA)

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Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates

Project description:Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates

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Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgA)

Project description:Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM63 IgA)

| PRJNA1019351 | ENA

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgA)

Project description:Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (NAPPA IgA)

| PRJNA1019353 | ENA

Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM30 IgM)

Project description:Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primates (LAM30 IgM)

| PRJNA1019349 | ENA

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