Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (snRNA-Seq)

ABSTRACT: SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (snRNA-Seq)

PROVIDER: PRJNA1019372 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR26129815_1.fastq.gz	Fastqsanger.gz
	SRR26129815_2.fastq.gz	Fastqsanger.gz
	SRR26129816_1.fastq.gz	Fastqsanger.gz
	SRR26129816_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

Project description:SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

| PRJNA1008700 | ENA

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (ChIP-Seq)

Project description:SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (ChIP-Seq)

| PRJNA1008703 | ENA

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (RNA-Seq)

Project description:SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (RNA-Seq)

| PRJNA1008704 | ENA

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (snRNA-Seq)

Project description:Myelination of neuronal axons is essential for nervous system development. Myelination requires dramatic cytoskeletal dynamics in oligodendrocytes, but how actin is regulated during myelination is poorly understood. We recently identified serum response factor (SRF)—a transcription factor known to regulate expression of actin and actin regulators in other cell types—as a critical driver of myelination in the aged brain. Yet, a major gap remains in understanding the fundamental role of SRF in oligodendrocyte lineage cells. Here we show that SRF is required cell autonomously in oligodendrocytes for myelination during development. Combining ChIP-seq with RNA-seq identifies SRF-target genes in OPCs and oligodendrocytes that include actin and other key cytoskeletal genes. Accordingly, SRF knockout oligodendrocytes exhibit dramatically reduced actin filament levels early in differentiation, consistent with its role in actin-dependent myelin sheath initiation. Together, our findings identify SRF as a transcriptional regulator that controls the expression of cytoskeletal genes required in oligodendrocytes for myelination. This study identifies a novel pathway regulating oligodendrocyte biology with high relevance to brain development, aging, and disease.

2024-02-23 | GSE243678 | GEO

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (RNA-Seq)

2024-02-23 | GSE241560 | GEO

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination (ChIP-Seq)

2024-02-23 | GSE241559 | GEO

SRF transcriptionally regulates the oligodendrocyte cytoskeleton during CNS myelination

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-02-23 | GSE241561 | GEO

MRTF/SRF link the cytoskeleton and hedgehog pathway in drug-resistant basal cell carcinomas

Project description:We use multi-dimensional genomic analysis using mouse resistant BCCs to identify a non-canonical hedgehog activation pathway driven by the transcription factor, serum response factor (SRF).

2018-01-25 | GSE78497 | GEO

Genome-wide maps of Wnt effector Tcf7l2/Tcf4 occupancy in oligodendrocyte during CNS myelination

Project description:We performed genome-wide profiling of Tcf7l2 occupancy during oligodendrocyte differentiation and identified the key enzymes involved in cholesterol metabolism and essential for CNS myelination. Examination of Tcf7l2 chIP-seq in oligodendrocyte progenitor cell and 2 differentiation oligodendrocytes.

2016-02-19 | E-GEOD-65119 | biostudies-arrayexpress

Role of fatty acid synthase in oligodendrocyte myelination

Project description:Role of fatty acid synthase in oligodendrocyte myelination

| PRJNA448839 | ENA