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Short-term cold exposure induces persistent epigenomic memory in brown fat [GRO-Seq]

ABSTRACT: Short-term cold exposure induces persistent epigenomic memory in brown fat [GRO-Seq]

PROVIDER: PRJNA1022503 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26226535.fastq.gz	Fastqsanger.gz
	SRR26226536.fastq.gz	Fastqsanger.gz
	SRR26226537.fastq.gz	Fastqsanger.gz
	SRR26226538.fastq.gz	Fastqsanger.gz
	SRR26226539.fastq.gz	Fastqsanger.gz

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Short-term cold exposure induces persistent epigenomic memory in brown fat [GRO-Seq]

Project description:Deficiency of the epigenome modulator histone deacetylase 3 (HDAC3) in brown adipose tissue (BAT) impairs the ability of mice to survive in near-freezing temperatures. Here, we report that short-term exposure to mild cold temperature (STEMCT: 15°C for 24 hours) averted lethal hypothermia of mice lacking HDAC3 in BAT (HDAC3 BAT KO) exposed to 4°C. STEMCT restored the induction of the thermogenic coactivator PGC-1a along with UCP1 at 22°C, which is greatly impaired in HDAC3-deficient BAT, and deletion of either UCP1 or PGC-1a prevented the protective effect of STEMCT. Remarkably, the protection of HDAC3 BAT KO mice from cold intolerance following STEMCT lasted for up to 7 days. Transcriptional activator C/EBPb was induced by short-term cold exposure in mouse and human BAT and, uniquely, remained high for 7 days following STEMCT. Furthermore, analysis of C/EBPb activity revealed increased binding following STEMCT at genes, including the enhancers/promotors of UCP1 and PGC-1a. These results reveal the existence of a cold-adaptive epigenomic memory mediated by C/EBPb that is persistent and HDAC3-independent.

2024-07-05 | GSE244384 | GEO

Short-term cold exposure induces persistent epigenomic memory in brown fat

Project description:Short-term cold exposure induces persistent epigenomic memory in brown fat

| PRJNA1022495 | ENA

Short-term cold exposure induces persistent epigenomic memory in brown fat [ChIP-Seq

2024-07-05 | GSE244383 | GEO

Short-term cold exposure induces persistent epigenomic memory in brown fat [ATAC-Seq]

2024-07-05 | GSE244382 | GEO

Short-term cold exposure induces persistent epigenomic memory in brown fat [RNA-Seq]

2024-07-05 | GSE244385 | GEO

Short-term cold exposure induces persistent epigenomic memory in brown fat [ATAC-Seq]

Project description:Short-term cold exposure induces persistent epigenomic memory in brown fat [ATAC-Seq]

| PRJNA1022502 | ENA

Short-term cold exposure induces persistent epigenomic memory in brown fat [ChIP-Seq

Project description:Short-term cold exposure induces persistent epigenomic memory in brown fat [ChIP-Seq

| PRJNA1022501 | ENA

Short-term cold exposure induces persistent epigenomic memory in brown fat [RNA-Seq]

Project description:Short-term cold exposure induces persistent epigenomic memory in brown fat [RNA-Seq]

| PRJNA1022504 | ENA

Short-term cold exposure induces persistent epigenomic memory in brown fat

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-02 | GSE244386 | GEO

LRP8-Reelin-regulated Neuronal (LRN) Enhancer signature underlying learning and memory formation (GRO-seq)

Project description:A comprehensive landscape of epigenomic events regulated by the Reelin signaling through activation of specific cohort of cis-regulatory enhancer elements (LRN-enhancers), which involves the proteolytical processing of the LRP8 receptor by the gamma-secretase activity and is required for learning and memory behavior All GRO-Seq experiments were designed to understand the unique signature of LRN-enhancers and to evaluate the transcriptional response to Reelin treatment in neuronal cells.

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