Project description:We created isogenic mutiple myeloma and mouse embryonic fibroblast cell lines disrupted for KDM6A using CRISPR editing and Cre-mediated deletion. To detect KDM6A we inserted a dual HA tag sequence into the C-terminal of KDM6A by CRISPR-mediated editing. We also created one isogenic cell line harboring a jmjD-dead KDM6A where 2 amino acids essential for KDM6A enzymatic activity, H1146 and E1148 , were replaced with alanine residues

2024-10-01 | GSE244510 | GEO

KDM6A Regulates Immunogenicity of Multiple Myeloma (ATAC-seq)

Project description:We created isogenic mutiple myeloma cell lines disrupted for KDM6A using CRISPR-mediated editing.

2024-10-01 | GSE244509 | GEO

KDM6A Regulates Immunogenicity of Multiple Myeloma (RNA-seq)

Project description:We created isogenic mutiple myeloma and mouse embryonic fibroblast cell lines disrupted for KDM6A using CRISPR editing and Cre-mediated deletion.

2024-10-01 | GSE244511 | GEO

KDM6A Regulates Immunogenicity of Multiple Myeloma

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-01 | GSE244512 | GEO

Multiple myeloma

Project description:Multiple myeloma

| PRJNA515992 | ENA

Multiple Myeloma cells

Project description:Multiple Myeloma cells

| PRJNA800411 | ENA

Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma

Project description:Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma