Project description:Cutibacterium acnes (C. acnes) is a ubiquitous skin commensal bacterium that is generally well tolerated by the immune system. Different strain-types of C. acnes have been reported to be enriched on patients with acne. To understand if these strain-types contribute to skin inflammation, we generated a library of over 200 C. acnes isolates from skin swabs of healthy and acne subjects and assessed their strain-level identity and inflammatory potential. Phylotype II K-type strains were more frequent on healthy and acne non-lesional skin compared to lesional. Phylotype IA-1 C-type strains were dominant on acne lesional skin but absent from healthy. Measurement of host cytokine responses from C. acnes supernatant revealed neither strain-type nor skin-type association predicted inflammatory potential. However, differential proinflammatory responses were induced from identical strain-types, but these differences were not attributable to protease, short chain fatty acid or porphyrin production. Instead, whole genome sequencing revealed the presence of a linear plasmid in high inflammatory strain-types. Intradermal injection of C. acnes in mouse skin revealed a plasmid-associated inflammatory response in dermal fibroblasts, revealed by single-cell RNA sequencing. We conclude that C. acnes strain-type is not sufficient to predict inflammation but other virulence factors including a plasmid may contribute to disease.

2023-08-18 | GSE211279 | GEO

Cutibacterium acnes subsp. acnes strain:11-90

Project description:Cutibacterium acnes subsp. acnes strain:11-90 Genome sequencing and assembly

| PRJNA373962 | ENA

Cutibacterium acnes subsp. acnes strain:10-118

Project description:Cutibacterium acnes subsp. acnes strain:10-118 Genome sequencing and assembly

| PRJNA373970 | ENA

Cutibacterium acnes subsp. acnes strain:12-89

Project description:Cutibacterium acnes subsp. acnes strain:12-89 Genome sequencing and assembly

| PRJNA373957 | ENA

Cutibacterium acnes subsp. acnes strain:11-88

Project description:Cutibacterium acnes subsp. acnes strain:11-88 Genome sequencing and assembly

| PRJNA373961 | ENA

Cutibacterium acnes subsp. acnes strain:10-113

Project description:Cutibacterium acnes subsp. acnes strain:10-113 Genome sequencing and assembly

| PRJNA373969 | ENA

Cutibacterium acnes strain:DSM 16379

Project description:Cutibacterium acnes strain:DSM 16379 Genome sequencing and assembly

| PRJNA429713 | ENA

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