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Transcriptome of nonpregnant myometrial specimens with or without the medroxyprogesterone treament

ABSTRACT: Transcriptome of nonpregnant myometrial specimens with or without the medroxyprogesterone treament

PROVIDER: PRJNA1024464 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26296252_1.fastq.gz	Fastqsanger.gz
	SRR26296252_2.fastq.gz	Fastqsanger.gz
	SRR26296253_1.fastq.gz	Fastqsanger.gz
	SRR26296253_2.fastq.gz	Fastqsanger.gz
	SRR26296254_1.fastq.gz	Fastqsanger.gz

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Transcriptome of nonpregnant myometrial specimens with or without the medroxyprogesterone treament

Project description:Timely control of parturition is crucial for maternal and fetal health. Failures on this biological process often result in pregnancy complications including preterm birth, labor dystocia, and health disorders on newborn babies. The myometrium is the muscular structure of the uterus maintaining uterine structural integrity and providing contractile force for parturition. The myometrial structure changes in adaptation to the pregnancy via stage-specific transcriptomic profiles. Progesterone signaling plays a crucial role in myometrial remodeling. The present study profiles the transcriptome of human myometrial specimens that are expected to manifest a wide spectrum of progesterone signaling via the RNAseq assay.

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Project description:Circulating progesterone (P4) levels decline before the onset of parturition in most animals, but not in humans. This has led to the suggestion that there is functional withdrawal of P4 action at the myometrial level prior to labor onset. Mifepristone is widely used to induce human labour In this study, we aimed to establish and validate a model of human myometrial explants for the study of P4 action. Myometrial biopsies obtained at Caesearean section at term were dissected into explants after a portion was immediately snap-frozen (t=0). Transcriptomic comparison of paired explants and primary myometrial cells as well as the hTert immortalized myometrial cell line demonstrated that explants more closely resemble t=0. Biopsies obtained from non-laboring women at elective Caesarean section at term were divided into 3: (i) dissected and immediately snap-frozen (t=0), (ii) dissected into 3x3x3mm3myometrial explants and (iii) processed for primary cell culture. Explants, primary cells at passage 4 (the typical passage our group uses for experiments) and hTERT cells were cultured for a period of 30 hours without treatment. Total RNA was extracted and microarray analysis performed. 6 replicates were used for this study.

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