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Decipher immune response in early recovery phase of respiratory virus-induced disorder

ABSTRACT: Decipher immune response in early recovery phase of respiratory virus-induced disorder

PROVIDER: PRJNA1024517 | ENA |

REPOSITORIES: ENA

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Decipher immune response in early recovery phase of respiratory virus-induced disorder [BAL scRNA-seq]

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Decipher immune response in early recovery phase of respiratory virus-induced disorder [Ly6GMacs scRNA-seq]

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Decipher immune response in early recovery phase of respiratory virus-induced disorder [BAL scRNA-seq]

Project description:Appropriate lung repair responses are essential to restore functional integrity and prevent severe disease phenotypes after injury. While macrophages are thought to contribute to repair, whether distinct subsets occupy particular niches and assume dedicated tasks to mediate host recovery post- injury remains unknown. Using an in vivo model of influenza A virus (IAV) infection in combination with single-cell and spatial transcriptomic analyses, bone marrow chimeras and monocyte fate-mapping, we found the transitional appearance of Ccr2-dependent monocyte-derived Ly6G+ macrophages (Ly6G Macs) after viral clearance. Ly6G Macs inhabited the alveolar spaces of regenerating perilesional areas, exhibited a unique ultrastructural morphology as well as a high metabolic potential. Using in vivo gene targeting and ex vivo wound healing assays, we found that Ly6G Macs could limit disease severity and promote alveolar regeneration via interleukin-4 receptor- and arginase-1-dependent mechanisms acting on type 2 alveolar epithelial cells. We also found evidence that similar macrophages existed in other models of lung injury and in the airways of virally-infected humans. Our study thus identifies perilesional alveolar Ly6G Macs as a spatially-restricted short-lived macrophage subset engaging a crosstalk with type 2 alveolar epithelial cells to promote alveolar regeneration and recovery post-injury, thus representing an attractive therapeutic target.

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Decipher immune response in early recovery phase of respiratory virus-induced disorder [Ly6GMacs scRNA-seq]

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Decipher immune response in early recovery phase of respiratory virus-induced disorder

Project description:This SuperSeries is composed of the SubSeries listed below.

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Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency

Project description:Reversible infantile respiratory chain deficiency (RIRCD) is a rare mitochondrial myopathy leading to severe metabolic disturbances in infants, which recover spontaneously after 6 months of age. RIRCD is associated with the homoplasmic m.14674T>C mitochondrial DNA mutation, however only ~1/100 carriers develop the disease. We studied 27 affected and 15 unaffected individuals from 19 families and found additional heterozygous mutations in nuclear genes interacting with mt-tRNAGlu including EARS2 and TRMU in the majority of affected individuals, but not in healthy carriers of m.14674T>C, supporting a digenic inheritance. The spontaneous recovery in infants with digenic mutations is modulated by changes in amino acid availability in a multi-step process. First, the integrated stress-response associated with increased FGF21 and GDF15 expression enhances catabolism via β-oxidation and the TCA cycle increasing the availability of amino acids. In the second phase mitochondrial biogenesis increases via mTOR activation, leading to improved mitochondrial translation and recovery. Similar mechanisms may explain the variable penetrance and tissue specificity of other mtDNA mutations and highlight the potential role of amino acids in improving mitochondrial disease.

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Transcription profiling of peripheral blood leukocyte genomic response one day post traumatic injury may predict early respiratory recovery

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