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Gene expression changes between term pregnant (TNIL) and labouring (LAB) human myometrium.

ABSTRACT: Gene expression changes between term pregnant (TNIL) and labouring (LAB) human myometrium.

PROVIDER: PRJNA1025024 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR26314914_1.fastq.gz	Fastqsanger.gz
	SRR26314914_2.fastq.gz	Fastqsanger.gz
	SRR26314915_1.fastq.gz	Fastqsanger.gz
	SRR26314915_2.fastq.gz	Fastqsanger.gz

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Gene expression changes between term pregnant (TNIL) and labouring (LAB) human myometrium.

Project description:We have generated transcriptomic datasets of the human uterine smooth muscle (myometrium) tissue. RNA-seq experiments were conducted to evaluate gene expression changes that occur as the uterus transitions from pregnancy to labour using human myometrium tissue.

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Gene regulatory markers in pregnant, term non-labouring, labouring, and postpartum myometrium.

Project description:Gene regulatory markers in pregnant, term non-labouring, labouring, and postpartum myometrium.

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Project description:The myometrium undergoes structural and functional remodeling during pregnancy. We hypothesize that myometrial genomic elements alter correspondingly in preparation for parturition. Human myometrial tissues from nonpregnant (NP) and term pregnant (TP) human subjects were subject to RNAseq, ATAC-seq and PGR ChIP-seq assays to profile transcriptome, assessible genome and PGR occupancy.

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Transcriptomic profile of the term pregnant human myometrial specimens

Project description:Timely control of parturition is crucial for maternal and fetal health. Failures on this biological process often result in pregnancy complications including preterm birth, labor dystocia, and health disorders on newborn babies. The myometrium is the muscular structure of the uterus maintaining uterine structural integrity and providing contractile force for parturition. The myometrial structure changes in adaptation to the pregnancy via stage-specific transcriptomic profiles. Data from the mouse model indicate that changes of myometrial epigenomic landscape precedes the adoption of stage-specific gene expression pattern at term. The present study documents the transcriptomic profile and epigenomic landscape of term pregnant myometrial tissues and functionally characterize a subset of putative enhancers to further understand the enhancer-gene interaction in human the myometrium.

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Immune cell distribution in the decidua and myometrium of pregnant mice at E7.5.

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IL-33+ cell subsets in the decidua and myometrium of pregnant mice at E7.5.

Project description:We used single cell RNA sequencing (scRNA-seq) to investigate the IL-33+ cell types present in the decidua and myometrium of pregnant mice at E7.5.

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Gene regulatory markers in pregnant, term non-labouring, labouring, and postpartum myometrium.

Project description:We have generated genome-wide binding and expression datasets in uterine smooth muscle (myometrium) from murine models of pregnancy and labour. ChIP-seq and total RNA-seq experiments were conducted to evaluate changes in the genomic and transcriptomic landscape of the myometrium prior to, during, and after labour onset.

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In Vivo Genome-wide PGR Binding in Pregnant Human Myometrium Identifies Potential Regulators of Labor [RNA-seq]

Project description:The alterations in myometrial biology during labor are not well understood. The myometrium is the contractile portion of the uterus and contributes to labor, a process that may be regulated by the steroid hormone progesterone. Thus, human myometrial tissues from term pregnant in-active-labor (TIL) and term pregnant not-in-labor (TNIL) subjects were used for genome-wide analyses to elucidate potential future preventive or therapeutic targets involved in the regulation of labor. Using myometrial tissues directly subjected to RNA sequencing (RNA-seq), progesterone receptor (PGR) chromatin immunoprecipitation sequencing (ChIP-seq), and histone modification ChIP-seq, we profiled genome-wide changes associated with gene expression in myometrial smooth muscle tissue in vivo. In TIL myometrium, PGR occupied predominatly promoter regions including the classical progesterone response element, whereas it bound predominantly to intergenic regions in TNIL myometrial tissue. Differential binding analysis uncovered over 1700 differential PGR-bound sites between TIL and TNIL with 1361 sites gained and 428 lost in labor. Functional analysis identified multiple pathways involved in cAMP-mediated signaling enriched in labor. A three-way integration of the data for ChIP-seq, RNA-seq and active histone marks uncovered the following genes associated with PGR binding, transcriptional activation and altered mRNA levels: ATP11A, CBX7, and TNS1. In vitro studies showed that ATP11A, CBX7, and TNS1 are progesterone responsive. We speculate that these genes may contribute to the contractile phenotype of the myometrium during various stages of labor. In conclusion, we provide novel labor associated genome-wide events and PGR-target genes that can serve as targets for future mechanistic studies.

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In Vivo Genome-wide PGR Binding in Pregnant Human Myometrium Identifies Potential Regulators of Labor [ChIP-seq]

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Genome-wide chromatin conformation capture of the term pregnant human myometrial specimens

Project description:Timely control of parturition is crucial for maternal and fetal health. Failures on this biological process often result in pregnancy complications including preterm birth, labor dystocia, and health disorders on newborn babies. The myometrium is the muscular structure of the uterus maintaining uterine structural integrity and providing contractile force for parturition. The myometrial structure changes in adaptation to the pregnancy via stage-specific transcriptomic profiles. Data from the mouse model indicate that changes of myometrial epigenomic landscape precedes the adoption of stage-specific gene expression pattern at term. The present study documents the chromatin interaction profiles in the term pregnant not in labor human myometrial tissues at a genome-wide scale.

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