Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [RNA-seq]

ABSTRACT: Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [RNA-seq]

PROVIDER: PRJNA1026106 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis

Project description:Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis

| PRJNA1026103 | ENA

Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [ChIP-seq]

Project description:Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [ChIP-seq]

| PRJNA1026105 | ENA

Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [scRNA-seq]

Project description:Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [scRNA-seq]

| PRJNA1026107 | ENA

Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [scRNA-seq]

Project description:Tumorigenesis, accompanied by tissue regenerative responses, always occurs during mammalian organ injury. In liver, injury context promotes dedifferentiated liver progenitor-like cells (LPLCs) from hepatocytes for regeneration, and also increases the occurrence of hepatocellular carcinoma (HCC). However, little is known about the contribution of injury specific LPLCs to tumorigenesis. Here, by using lineage tracing model, we have demonstrated that LPLCs are highly susceptible to oncogene-induced tumorigenesis. By using quantitative landscape of differentiation dynamics (LDD) model, we have constructed potential landscape of liver regeneration and tumorigenesis via scRNA-seq data, in order to predict distinct regulations of cell fate decisions. Applying this landscape with in vivo validation by transgenic mouse model, we have found blocking Wnt activation not only inhibits tumorigenesis, but also decreases LPLCs. Surprisingly, by using least action pathway analysis, we have decomposed regeneration and tumorigenesis routes, and found EP300 is specifically involved in tumorigenesis, which is further supported by in vivo EP300-knockout model and EP300 inhibitor assays. These findings might be applied as a framework to find tumor-specific regulators and develop strategies specifically inhibiting tumor initiation while leaving tissue regeneration unaffected.

2024-09-29 | GSE244911 | GEO

Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [RNA-seq]

2024-09-29 | GSE244910 | GEO

Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis [ChIP-seq]

2024-09-29 | GSE244909 | GEO

Potential landscape decomposes the cell identity conversion in liver regeneration and tumorigenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-09-29 | GSE244912 | GEO

Club cells employ regeneration mechanisms during lung tumorigenesis

Project description:Club cells employ regeneration mechanisms during lung tumorigenesis

| PRJNA735234 | ENA

Club cells employ regeneration mechanisms during lung tumorigenesis