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Gut Microbiome Characteristics in Patients With Pediatric Solid Tumor

ABSTRACT: Gut Microbiome Characteristics in Patients With Pediatric Solid Tumor Raw sequence reads

PROVIDER: PRJNA1026296 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26329523_1.fastq.gz	Fastqsanger.gz
	SRR26329523_2.fastq.gz	Fastqsanger.gz
	SRR26329524_1.fastq.gz	Fastqsanger.gz
	SRR26329524_2.fastq.gz	Fastqsanger.gz
	SRR26329525_1.fastq.gz	Fastqsanger.gz

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Project description:BackgroundPediatric solid tumor, the abnormal proliferation of solid tissues in children resulting in the formation of tumors, represent a prevailing malignant ailment among the younger population. Extensive literature highlights the inseparable association linking oral microbiome and adult tumors, but due to differences in age of onset, characteristics of onset, etc., there are many differences between Pediatric solid tumors and adult tumors, and therefore, studying the relationship between Pediatric solid tumor and the oral microbiota is also essential.MethodsTo unravel the distinct characteristics of the oral microbiota within Pediatric solid tumor patients, 43 saliva samples, encompassing 23 Pediatric solid tumor patients and 20 healthy controls, were diligently procured. A meticulous screening process ensued, and conducted microbial MiSeq sequencing after screening.ResultsWe documented the oral microbiome attributes among pediatric diagnosed with solid tumors (PST), and meanwhile, we observed a significant trend of decreased oral microbiota diversity in the pediatric solid tumor group. There were notable disparities in microbial communities observed between the two groups, 18 genera including Veillonellaceae, Firmicutes unclassified, Coriobacteriia, Atopobiaceae, Negativicutes, were significantly enriched in PST patients, while 29 genera, including Gammaproteobacteria, Proteobacteria, Burkholderiales, Neisseriaceae, were dominant in the HCs group. It was found that PST group had 16 gene functions, including Amino acid metabolism, Cysteine and methionine metabolism, Photosynthesis antenna proteins, Arginine and proline metabolism, and Aminoacyl tRNA biosynthesi, were significantly dominant, while 29 gene functions that prevailed in HCs.ConclusionThis study characterized the oral microbiota of Pediatric solid tumor patients for the first time, and importantly, targeted biomarkers of oral microbiota may serve as powerful and non-invasive diagnostic tools for pediatric solid tumor patients.

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Gut Microbiome Characteristics in Patients With Pediatric Solid Tumor

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