Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation

ABSTRACT: CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation

PROVIDER: PRJNA1026639 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [RNA-seq]

Project description:CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [RNA-seq]

| PRJNA1020107 | ENA

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [CR-N_mice_scRNA-seq]

Project description:CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [CR-N_mice_scRNA-seq]

| PRJNA1039810 | ENA

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [human CD34+ cells_CUT-Tag seq_HDAC3]

Project description:CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [human CD34+ cells_CUT-Tag seq_HDAC3]

| PRJNA1142161 | ENA

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [CUT&Tag in CD34+ cells]

Project description:CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [CUT&Tag in CD34+ cells]

| PRJNA1026615 | ENA

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [human CD34+ cells_CUT-Tag seq_ H3K27me3]

Project description:CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [human CD34+ cells_CUT-Tag seq_ H3K27me3]

| PRJNA1142160 | ENA

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [BM Mac1+ and c-kit+ cells RNA-seq]

Project description:CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [BM Mac1+ and c-kit+ cells RNA-seq]

| PRJNA1026643 | ENA

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [RNA-seq]

Project description:Acute myeloid leukemia (AML) with RARG fusions, which clinic features resemble acute promyelocytic leukemia (APL), have been identified as a new subtype with poor clinical outcomes. The underlying mechanism of RARG fusion is poorly understood, which needs to be explored urgently to develop effective therapeutic strategies. Using hematopoietic specific knock-in mouse model and xenograft mouse model transplanted with oncogene transduced human CD34+ cells, we revealed that CPSF6-RARG (CR) fusion, one of the most prevalent recurrent RARG translocations, enhances expansion of immature cells and impairs myeloid maturation, synergizing with RAS mutation to drive more aggressive myeloid malignancies. Mechanistically, CR recruits the histone deacetylase 3 (HDAC3) to suppress the transcription of PU.1, a key transcription factor for myeloid lineage specification. CR driven leukemia is more sensitive to HDAC inhibitors in vitro and in vivo. Hence, our data reveals the molecular bases of the oncogenic CR fusion and provides a potential targeted therapeutic approach against AML with CR fusions.

2024-10-24 | GSE243817 | GEO

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [CR-N_mice_scRNA-seq]

2024-10-24 | GSE247606 | GEO

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [human CD34+ cells_CUT-Tag seq_HDAC3]

2024-10-24 | GSE273551 | GEO

CPSF6-RARγ Interacts with HDAC3 to Promote Myeloid Transformation [CUT&Tag in CD34+ cells]

2024-10-24 | GSE245012 | GEO