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Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus - pooled embryonic Fzd10 lineage

ABSTRACT: Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus - pooled embryonic Fzd10 lineage

PROVIDER: PRJNA1026954 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR26359211.fastq.gz	Fastqsanger.gz

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Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

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Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus - pooled embryonic Fzd10 lineage

Project description:The superior colliculus (SC) in the mammalian midbrain is essential for multisensory integration and is composed of a rich diversity of excitatory and inhibitory neurons and glia. The developmental principles directing the generation of SC cell-type diversity are however not understood. Here we pursued systematic cell lineage tracing in silico and in vivo, preserving full spatial information, using genetic MADM (Mosaic Analysis with Double Markers)-based clonal analysis with single-cell sequencing (MADM-CloneSeq). The analysis of clonally-related cell lineages revealed that radial glial progenitor (RGP) cells in SC are exceptionally multipotent. Individual resident RGPs have the capacity to produce all excitatory and inhibitory SC neuron types, even at the stage of terminal division. While individual clonal units show no pre-defined cellular composition, the establishment of appropriate relative proportions of distinct neuronal types occurs in a PTEN-dependent manner. Collectively, our findings provide an inaugural framework at single RGP/cell level of the mammalian SC ontogeny

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Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – MADM-CloneSeq E10

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Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

Project description:This SuperSeries is composed of the SubSeries listed below.

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Effects of eye opening on gene expression in the superficial layers of the rat superior colliculus

Project description:We performed RNA-seq on six samples of P20 Sprague Dawley rat superior colliculus, three control rats that underwent eye opening at P14 until P20 and three deprived rats which had their eyes glued closed from P14 until P20. Each sample was created from two pooled colliculi. RNA-seq of the superior colliculus with and without long term light deprivation.

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