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Transcriptome-wide analysis of hidradenitis suppurativa

ABSTRACT: Transcriptome-wide analysis of hidradenitis suppurativa

PROVIDER: PRJNA1028532 | ENA |

REPOSITORIES: ENA

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Transcriptome-wide analysis of hidradenitis suppurativa

Project description:The aim of this study was to obtain a better understanding of the molecular background of hidradenitis suppurativa (HS). Global transcriptome analysis of lesional and perilesional skin identifies numerous differentially expressed genes that display unique expression pattern in HS. Genes, whose expression is dysregulated in the skin of patients suffering from HS are novel biomarker candidates and potential therapeutic targets for HS.

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Project description:Hidradenitis Suppurativa (HS) is a debilitating chronic inflammatory disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Through the use of transcriptomic approaches, we characterize the inflammatory responses in HS in depth, revealing the cell types and immune responses involved.

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Project description:Hidradenitis suppurativa (HS), also termed acne inversa, is a persistent inflammatory dermatological condition affecting approximately 1% of the global population, causing significant morbidity. The etiology of HS is not fully elucidated, but it is known that immune dysfunction plays a critical role. In our research to discern the role of non-coding RNA in HS, we initially conducted a comparative analysis of the most significantly altered long non-coding RNA (lncRNA) and mRNA expressions.

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Project description:Molecular taxonomy and key signaling pathways of apocrine glands of patients with hidradenitis suppurativa were studied by whole transcriptome profiling. Dysregulated genes were detected by comparing lesional and non lesional skin obtained from male and female HS patients using the Agilent array platform.

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Single cell transcriptome profiling for hidradenitis suppurativa

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RNA sequencing of skin punch biopsies of lesional and non-lesional skin from hidradenitis suppurativa patients

Project description:This study investigated the underlying inflammatory pathways and cell types in hidradenitis suppurativa using transcriptomic approaches with RNA sequencing of lesional and non-lesional skin biopsies from hidradenitis suppurativa patients.

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