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Effect of housing condition (group- or single-housing) on gene expression in African turquoise killifish I.

ABSTRACT: Effect of housing condition (group- or single-housing) on gene expression in African turquoise killifish I.

PROVIDER: PRJNA1028581 | ENA |

REPOSITORIES: ENA

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Effect of housing condition (group- or single-housing) on gene expression in African turquoise killifish II.

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Effect of housing condition (group- or single-housing) on gene expression in African turquoise killifish I.

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Project description:Effect of housing condition (group- or single-housing) on gene expression in African turquoise killifish II.

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Circular RNAs in the ageing African turquoise killifish

Project description:In this work we took 9 samples from brain and 6 samples from muscle of the African turquoise killifish (Nothobranchius furzeri) at 3.5, 8.5 and 14 weeks. Total RNA was sequenced and circRNAs were detected.

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Effect of housing condition (group- or single-housing) on gene expression in African turquoise killifish

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-10-13 | GSE245483 | GEO

Effect of ageing on gene expression in the African turquiose killifish retina

Project description:The mammalian central nervous system (CNS) is susceptible to age-related pathologies, resulting in progressive, irreversible disease. Neurodegenerative eye conditions, like glaucoma and age-related macular degeneneration (AMD), are on the rise due to increased life expectancy. Despite this, there are currently no long-term therapies to prevent degeneration and vision loss. The short-lived African turquoise kililfsh (Nothobranchius furzeri GRZ-AD) is an ideal genetic model for ageing studies, exhibiting rapid ageing phenotypes within its four to six-mont lifespan. Investigating the molecular consequences of ageing in the retina, we conducted bulk RNA-sequencing, revealing dysregulation of genetic pathways associated with ageing CNS and retinal diseas in the aged killifish retina.

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